ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2008
Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Event-related Oscillations to Emotional Faces are Related to a History of Internalizing Disorders.Clinical EEG and neuroscience · 2023Article
- Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk.Behavioral sciences (Basel, Switzerland) · 2020Article
- Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample.Drug and alcohol dependence · 2016Article
- Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015Article
- Variant calling in low-coverage whole genome sequencing of a Native American population sample.BMC genomics · 2014Article
- Measuring historical trauma in an American Indian community sample: contributions of substance dependence, affective disorder, conduct disorder and PTSD.Drug and alcohol dependence · 2013Article
- Evidence for a genetic component for substance dependence in Native Americans.The American journal of psychiatry · 2013Review
- Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD.Journal of psychiatric research · 2013Article
- Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study.Psychiatric genetics · 2012Article
- American Indians with substance use disorders: treatment needs and comorbid conditions.The American journal of drug and alcohol abuse · 2012Article
- Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Genome-wide association study of conduct disorder symptomatology.Molecular psychiatry · 2011Article
- Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study.Drug and alcohol dependence · 2011Article
- Genome-wide scan for self-rating of the effects of alcohol in American Indians.Psychiatric genetics · 2010Article
- Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.Addiction biology · 2010Review
- EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study.BMC medical genetics · 2010Article
- EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study.Drug and alcohol dependence · 2010Article
- Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community.Addiction biology · 2009Article
- Age at regular drinking, clinical course, and heritability of alcohol dependence in the San Francisco family study: a gender analysis.The American journal on addictionsArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Alcohol dependence is one of the leading causes of morbidity and mortality in Native Americans. Externalizing disorders such as conduct disorder (CD) and antisocial personality disorder (ASPD) have been demonstrated to have significant comorbidity with alcohol dependence in the general population. This study's aims were to: assess the comorbidity of DSM-III-R ASPD and CD with alcohol dependence, to map susceptibility loci for ASPD and CD, and to see if there is overlap with loci previously mapped for alcohol dependence phenotypes in 587 American Indians. Alcohol dependence was found to be comorbid with DSM-III-R ASPD but not CD. However, the amount of alcohol dependence in the population attributable to ASPD and/or CD is low. ASPD and the combined phenotype of participants with ASPD or CD were both found to have significant heritability, whereas no significant evidence was found for CD alone. Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 251 of the participants. Analyses of multipoint variance component LOD scores, for ASPD and ASPD/CD, revealed six locations that had a LOD score of 2.0 or above: on chromosome 13 for ASPD and on chromosomes 1, 3, 4, 14, 17, and 20 for ASPD/CD. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies for externalizing diagnoses. These results also further identify new regions of the genome, that do not overlap with alcohol dependence phenotypes previously identified in this population, that may be unique to either the phenotypes evaluated or this population of American Indians.
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