ReviewBiopolymers2008
A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET.
Review in Biopolymers, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Impacts of ribosomal RNA sequence variation on gene expression and phenotype.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Dissecting the mechanism of atlastin-mediated homotypic membrane fusion at the single-molecule level.Nature communications · 2024Article
- Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction.Chemical science · 2021Article
- Quantitative Modeling of Protein Synthesis Using Ribosome Profiling Data.Frontiers in molecular biosciences · 2021Review
- Measuring mRNA translation in neuronal processes and somata by tRNA-FRET.Nucleic acids research · 2020Article
- Engineering Allostery into Proteins.Advances in experimental medicine and biology · 2019Review
- Toward dynamic structural biology: Two decades of single-molecule Förster resonance energy transfer.Science (New York, N.Y.) · 2018Review
- Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.Biochemistry · 2016Review
- Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis.Molecular cell · 2015Article
- Function and dynamics of macromolecular complexes explored by integrative structural and computational biology.Current opinion in structural biology · 2014Review
- Structural basis for protein synthesis: snapshots of the ribosome in motion.Current opinion in structural biology · 2012Review
- Real-time evidence for EF-G-induced dynamics of helix 44 in 16S rRNA.Journal of molecular biology · 2012Article
- Computational studies of molecular machines: the ribosome.Current opinion in structural biology · 2012Review
- Functional dynamics of proteins.Computational and mathematical methods in medicine · 2012Article
- Mechanistic insights into antibiotic action on the ribosome through single-molecule fluorescence imaging.Annals of the New York Academy of Sciences · 2011Review
- Brownian dynamics study of the association between the 70S ribosome and elongation factor G.Biopolymers · 2011Article
- From DNA to proteins via the ribosome: structural insights into the workings of the translation machinery.Human genomics · 2010Review
- Aminoglycoside activity observed on single pre-translocation ribosome complexes.Nature chemical biology · 2010Article
- Aminoglycoside activity observed on single pre-translocation ribosome complexes.Nature chemical biology · 2010Article
- Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function.Biophysical reviews · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This article reviews the application of single-molecule fluorescence resonance energy transfer (smFRET) methods to the study of protein synthesis catalyzed by the ribosome. smFRET is a powerful new technique that can be used to investigate dynamic processes within enzymes spanning many orders of magnitude. The application of wide-field smFRET imaging methods to the study of dynamic processes in the ribosome offers a new perspective on the mechanism of protein synthesis. Using this technique, the structural and kinetic parameters of tRNA motions within wild-type and specifically mutated ribosome complexes have been obtained that provide valuable new insights into the mechanism and regulation of translation elongation. The results of these studies are discussed in the context of current knowledge of the ribosome mechanism from both structural and biophysical perspectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.