Evidence map›Paper›PMID 18286226›Full record

ArticleJournal of human genetics2008

Mitochondrial DNA polymorphisms and haplogroups in Parkinson's disease and control individuals with a similar genetic background.

Helen Latsoudis, Cleanthe Spanaki, Grigoris Chlouverakis, Andreas Plaitakis

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  9. Frontiers in neuroscience · 2018
    Review
  10. Article
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  15. Article
  16. Article
  17. POLG1-related and other "mitochondrial Parkinsonisms": an overview.Journal of molecular neuroscience : MN · 2011
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Helen LatsoudisDepartment of Neurology, University of Crete, Medical School, Voutes and Staurakia, 71103, Heraklion, Crete, Greece.
Cleanthe SpanakiDepartment of Neurology, University of Crete, Medical School, Voutes and Staurakia, 71103, Heraklion, Crete, Greece.
Grigoris ChlouverakisDepartment of Biostatistics, University of Crete, Crete, Greece.
Andreas PlaitakisDepartment of Neurology, University of Crete, Medical School, Voutes and Staurakia, 71103, Heraklion, Crete, Greece. plaitak@med.uoc.gr.
University of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial complex I deficiency has been implicated in the pathogenesis of Parkinson's disease (PD), but as yet no mitochondrial DNA (mtDNA) variations have been identified that could account for the impaired complex I activity. On the other hand, it has been suggested that mtDNA polymorphisms (mtSNPs) or haplogroups may modify the risk of developing PD. Here, we determined the distributions of ten mtSNPs that define the nine major European haplogroups among 224 PD patients and 383 controls from Crete, an island of 0.6 million inhabitants who share a similar genetic background and a common environment. The recruitment of patients and controls was restricted to individuals of Cretan origin for at least three generations from both parental sides in order to avoid population admixture and subsequent genetic heterogeneity. We found no mtSNP or mtDNA haplogroup that predisposes to PD, although there was a trend for haplogroups J, T, U and I and the supercluster of haplogroups UKJT to be slightly underrepresented in our PD patients as compared to controls. While a combination of common mtSNPs (present in >or=5% of the general population) may decrease the chance of developing PD, this effect was minor in the Cretan population.

Indexed as

Polymorphism, GeneticDNA, MitochondrialGenetic Predisposition to DiseaseGenotypeGreeceHaplotypesHumansParkinson DiseaseWhite PeopleDNA, Mitochondrial

Identifiers

PMID18286226
OpenAlexW2093140418

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.