SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Effect of calcium supplementation on hip fractures.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.BMC geriatrics · 2024Pooled it
- Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials.The Journal of clinical endocrinology and metabolism · 2012Pooled it
- 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010Guideline
- Bone health nutrition issues in aging.Nutrients · 2010Pooled it
- Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis.BMJ (Clinical research ed.) · 2010Pooled it
- The Auckland calcium study: 5-year post-trial follow-up.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Trial
- Calcium supplementation increases blood creatinine concentration in a randomized controlled trial.PloS one · 2014Trial
- Effect of Denosumab on Bone Density in Postmenopausal Osteoporosis: A Comparison with and without Calcium Supplementation in Patients on Standard Diets in Korea.Journal of clinical medicine · 2023Article
- Investigating changes in calcium, phosphorus, alkaline phosphatase, and 25-hydroxy Vitamin D after surgical repair of fractures of femur or tibia.Acta bio-medica : Atenei Parmensis · 2020Article
- Does serum calcium relate to different types of hip fracture? A retrospective study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2016Article
- Lifestyle and osteoporosis.Current osteoporosis reports · 2015Review
- Osteoporosis: The connection to urologic health.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2014Review
- Calcium balance and negative impact of calcium load in peritoneal dialysis patients.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2014Review
- Vitamin D: an examination of physician and patient management of health and uncertainty.Qualitative health research · 2014Article
- Calcium revisited: part II calcium supplements and their effects.BoneKEy reports · 2014Review
- Vitamin D supplements with or without calcium to prevent fractures.BoneKEy reports · 2014Review
- Calcium: too much of a good thing?Journal of women's health (2002) · 2013Article
- Clinical practice. Calcium supplements and fracture prevention.The New England journal of medicine · 2013Review
- Calcium supplements and cardiovascular risk: 5 years on.Therapeutic advances in drug safety · 2013Review
- Cardiovascular effects of calcium supplements.Nutrients · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been numerous studies of the effects of calcium supplementation, with or without vitamin D, on fractures. Individually, they have not provided clarity regarding calcium's anti-fracture efficacy, though they have established that calcium does have beneficial effects on bone density throughout the skeleton in women. Meta-analysis of these data suggests that total fracture numbers are diminished. However, the data from the 5,500 women involved in trials of calcium monotherapy show consistent adverse trends in numbers of hip fractures (relative risk 1.50, 95% CI 1.06-2.12). Observational data from the Study of Osteoporotic Fractures show a similar increase in risk of hip fracture associated with calcium use. We hypothesize that reduced periosteal expansion in women using calcium supplementation might account for the differences in anti-fracture efficacy of calcium at the hip, in comparison with other sites. Until there are further trial results to clarify this area, the present findings suggest that reliance on high calcium intakes to reduce the risk of hip fracture in older women is not appropriate. In addition, those at risk should be looking to other agents with a proven capacity to prevent hip fractures, such as bisphosphonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.