Evidence map›Paper›PMID 18285809›Full record

ArticleEuropean journal of clinical nutrition2009

Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size.

H J W Farrant, G V Krishnaveni, J C Hill, B J Boucher, D J Fisher, K Noonan, C Osmond, S R Veena, C H D Fall

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02215213 (Assessment of Dose Effectiveness of Vitamin D Supplementation During Pregnancy), which is not on this map. Cited by 100 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 13 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02215213 nacompletednot on this mapstarted 2013, after this paper: background citation

Assessment of Dose Effectiveness of Vitamin D Supplementation During Pregnancy

TypeinterventionalSponsorAga Khan UniversityRan2013 to 2016Enrolled350ConditionsPregnancyArmsVitamin D supplement
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 13 syntheses or guidelines pooled it, 253 citations in OpenAlex.

  1. Pooled it
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  5. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
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  8. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes.The Journal of steroid biochemistry and molecular biology · 2016
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  13. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2012
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  14. Trial
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

H J W FarrantMRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK.
G V Krishnaveni
J C Hill
B J Boucher
D J Fisher
K Noonan
C Osmond
S R Veena
C H D Fall
University of Southampton · GBCSI Holdsworth Memorial Hospital · INBarts Health NHS Trust · GBQueen Mary University of London · GB

Funding

Department of HealthMedical Research Council G0400519Medical Research Council G0400519(71108)Medical Research Council MC_U147574246Medical Research Council MC_U147585821Medical Research Council U.1475.00.004.00005.01(74246)Medical Research Council U.1475.00.004.00005.01 (85821)Wellcome Trust 059609Wellcome Trust 079877
6 · The paper itself

Abstract

BACKGROUND/

objectivesVitamin D is required for bone growth and normal insulin secretion. Maternal hypovitaminosis D may impair fetal growth and increase the risk of gestational diabetes. We have related maternal vitamin D status in pregnancy to maternal and newborn glucose and insulin concentrations, and newborn size, in a South Indian population. SUBJECTS/

methodsSerum 25 hydroxy vitamin D (25(OH)D) concentrations, glucose tolerance, and plasma insulin, proinsulin and 32-33 split proinsulin concentrations were measured at 30 weeks gestation in 559 women who delivered at the Holdsworth Memorial Hospital, Mysore. The babies' anthropometry and cord plasma glucose, insulin and insulin precursor concentrations were measured.

resultsIn total 66% of women had hypovitaminosis D (25(OH)D concentrations <50 nmol l(-1)) and 31% were below 28 nmol l(-1). There was seasonal variation in 25(OH)D concentrations (P<0.0001). There was no association between maternal 25(OH)D and gestational diabetes (incidence 7% in women with and without hypovitaminosis D). Maternal 25(OH)D concentrations were unrelated to newborn anthropometry or cord plasma variables. In mothers with hypovitaminosis D, higher 25(OH)D concentrations were associated with lower 30-min glucose concentrations (P=0.03) and higher fasting proinsulin concentrations (P=0.04).

conclusionsHypovitaminosis D at 30 weeks gestation is common in Mysore mothers. It is not associated with an increased risk of gestational diabetes, impaired fetal growth or altered neonatal cord plasma insulin secretory profile.

Indexed as

Blood GlucoseAdultBirth WeightBody SizeCalcifediolDiabetes, GestationalFemaleFetal BloodHumansIndiaInfant, NewbornPregnancyProinsulinSeasonsVitamin D DeficiencyYoung AdultBlood GlucoseCalcifediolProinsulin

Identifiers

PMID18285809
PMCPMC2678985
OpenAlexW2007184550

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.