ArticleDiabetes care2008
Circulating surfactant protein A (SP-A), a marker of lung injury, is associated with insulin resistance.
Article in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02889510 (Multicentre Randomized Double Blind, Crossover, Placebo Controlled Clinical Trial to Evaluate the Effect of Liraglutide on Lung Function in Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicentre Randomized Double Blind, Crossover, Placebo Controlled Clinical Trial to Evaluate the Effect of Liraglutide on Lung Function in Patients With Type 2 Diabetes Mellitus (LIRALUNG Study)
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Development and External Validation of a Prediction Model for Hypoxemia After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: a Multicenter Retrospective Study.Obesity surgery · 2026Article
- Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies.Frontiers in pharmacology · 2025Review
- Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus.Disease models & mechanisms · 2024Article
- Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.Scientific reports · 2024Article
- Article
- Unrestrained eating behavior and risk of mortality: A prospective cohort study.Clinical nutrition (Edinburgh, Scotland) · 2021Article
- When Two Pandemics Meet: Why Is Obesity Associated with Increased COVID-19 Mortality?Med (New York, N.Y.) · 2020Review
- Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin.PloS one · 2020Article
- The Serum Level of KL-6 Is Associated with the Risk of Insulin Resistance and New-onset Diabetes Mellitus: The Tanno-Sobetsu Study.Internal medicine (Tokyo, Japan) · 2017Article
- Antimicrobial-sensing proteins in obesity and type 2 diabetes: the buffering efficiency hypothesis.Diabetes care · 2011Review
- Type 2 diabetes impairs pulmonary function in morbidly obese women: a case-control study.Diabetologia · 2010 · on this mapArticle
- Fatty diabetic lung: altered alveolar structure and surfactant protein expression.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- A cross-sectional relationship between vital capacity and metabolic syndrome and between vital capacity and diabetes in a sample Japanese population.Environmental health and preventive medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesImpaired lung function and inflammation have both attracted interest as potentially novel risk factors for glucose intolerance, insulin resistance, and type 2 diabetes. We hypothesized that circulating levels of surfactant protein (SP)-A, which reflects interstitial lung injury, could be associated with altered glucose tolerance and insulin resistance. RESEARCH DESIGN AND
methodsCirculating SP-A concentration and metabolic variables (including insulin sensitivity by minimal model method, n = 89) were measured in 164 nonsmoking men.
resultsCirculating SP-A concentration was significantly higher among patients with glucose intolerance and type 2 diabetes than in subjects with normal glucose tolerance, even after adjustment for BMI, age, and smoking status (ex/never). The most significant differences were found in overweight and obese subjects with altered glucose tolerance (n = 59) who showed significantly increased serum SP-A concentrations (by a mean of 24%) compared with obese subjects with normal glucose tolerance (n = 58) (log SP-A 1.54 +/- 0.13 vs. 1.44 +/- 0.13; P < 0.0001). Insulin sensitivity (P = 0.003) contributed independently to 22% of SP-A variance among all subjects. In subjects with altered glucose tolerance, insulin sensitivity (P = 0.01) and fasting triglycerides (P = 0.02) contributed to 37% of SP-A variance. Controlling for serum creatinine or C-reactive protein in these models did not significantly change the results.
conclusionsLung-derived SP-A protein was associated with altered glucose tolerance and insulin resistance in 164 nonsmoking men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.