ArticleAntimicrobial agents and chemotherapy2008
Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Corallopyronin A exhibits potent activity against staphylococci including MRSA and isolates from prosthetic infections.Infection · 2026Article
- The road to success of coagulase-negative staphylococci: clinical significance of small colony variants and their pathogenic role in persistent infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Review
- Extracellular DNA released by glycine-auxotrophic Staphylococcus epidermidis small colony variant facilitates catheter-related infections.Communications biology · 2021Article
- Article
- Bacterial biofilm formation is variably inhibited by different formulations of antibiotic-loaded bone cement in vitro.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease.Antimicrobial agents and chemotherapy · 2018Article
- The Electron Transport Chain Sensitizes Staphylococcus aureus and Enterococcus faecalis to the Oxidative Burst.Infection and immunity · 2017Article
- Influence ofAntimicrobial agents and chemotherapy · 2017Article
- High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model.Antimicrobial agents and chemotherapy · 2017Article
- Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii.International journal of antimicrobial agents · 2016Article
- Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2016Article
- Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2016Article
- Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections.Clinical microbiology reviews · 2016Review
- Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations.Antimicrobial agents and chemotherapy · 2016Article
- Article
- Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure.Antimicrobial agents and chemotherapy · 2015Article
- Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.Antimicrobial agents and chemotherapy · 2015Article
- Staphylococcus aureus adapts to oxidative stress by producing H2O2-resistant small-colony variants via the SOS response.Infection and immunity · 2015Article
- Evolution of Staphylococcus aureus under vancomycin selective pressure: the role of the small-colony variant phenotype.Antimicrobial agents and chemotherapy · 2015Article
- Phenotypic and Genotypic Characteristics of Small Colony Variants and Their Role in Chronic Infection.Microbiology insights · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.