Evidence map›Paper›PMID 18285475›Full record

ArticleAntimicrobial agents and chemotherapy2008

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes.

Chun-Ming Huang, Justin W Torpey, Yu-Tseung Liu, Yun-Ru Chen, Katherine E Williams, Elizabeth A Komives, Richard L Gallo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chun-Ming HuangDivision of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm. 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA. chunming@ucsd.edu
Justin W Torpey
Yu-Tseung Liu
Yun-Ru Chen
Katherine E Williams
Elizabeth A Komives
Richard L Gallo

Funding

Yessinia autotransporters (Yaps): Structure, function, and host responseU54AI057157 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWE, JAMES E · 2003 to 2013
$91.4M
Immunological Secretomes of the Early Anthrax InfectionR01AI067395 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI HUANG, CHUN-MING · 2006 to 2010
$1.2M
NIAID NIH HHS 1-R01 AI067395NIAID NIH HHS 5 U54 AI057157-02NIAID NIH HHS R01 AI067395NIAID NIH HHS U54 AI057157PHS HHS R21-I58002-01PHS HHS R21-R022754-01
6 · The paper itself

Abstract

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

Indexed as

AdultAmino Acid SequenceFemaleGlutamineHumansMaleMicroscopy, FluorescenceMolecular Sequence DataPeptidesProlinePropionibacterium acnesSalivaSalivary Proteins and PeptidesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationGlutaminePeptidesProlineSalivary Proteins and Peptides

Identifiers

PMID18285475
PMCPMC2346631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.