ArticleMolecular and cellular biology2008
RalGDS couples growth factor signaling to Akt activation.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway.Oncology reports · 2020Article
- Insulated Switches: Dual-Function Protein RalGEFInternational journal of molecular sciences · 2020Article
- Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population.Clinical epigenetics · 2020Article
- Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.NMR in biomedicine · 2019Review
- Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals.PLoS genetics · 2019Article
- Structure, signaling and the drug discovery of the Ras oncogene protein.BMB reports · 2017Review
- Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway.PloS one · 2017Article
- Article
- RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS.Cell death & disease · 2015Article
- Cdc42p-interacting protein Bem4p regulates the filamentous-growth mitogen-activated protein kinase pathway.Molecular and cellular biology · 2015Article
- Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.Biochimica et biophysica acta · 2014Review
- Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.The Journal of biological chemistry · 2013Article
- The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex.The Journal of biological chemistry · 2013Article
- The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis.PloS one · 2013Article
- Ras family of small GTPases in immunity and inflammation.Current opinion in pharmacology · 2012Review
- The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras.Molecular cell · 2012Article
- Early thyroid hormone-induced gene expression changes in N2a-β neuroblastoma cells.Journal of molecular neuroscience : MN · 2011Article
- Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Nature reviews. Cancer · 2010Review
- Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.The Journal of biological chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Akt kinase is a key regulator of cell proliferation and survival. It is activated in part by PDK1-induced phosphorylation. Here we show that RalGDS, a Ras effector protein that activates Ral GTPases, has a second function that promotes Akt phosphorylation by PDK1 by bringing these two kinases together. In support of this conclusion is our finding that suppression of RalGDS expression in cells inhibits both epidermal growth factor and insulin-induced phosphorylation of Akt. Moreover, while PDK1 complexes with N-GDS, Akt complexes with the central region of RalGDS through an intermediary, JIP1. The biological significance of this newly discovered RalGDS function is highlighted by the observation that an N-terminally deleted mutant of RalGDS that retains the ability to activate Ral proteins but loses the ability to activate Akt also fails to promote cell proliferation. Thus, RalGDS forms a nexus that transduces growth factor signaling to both Ral GTPase and Akt-mediated signaling cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.