ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2008
Cannabinoid CB1 receptors are expressed by parietal cells of the human gastric mucosa.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint.Animals : an open access journal from MDPI · 2022Review
- The Peripheral Cannabinoid Receptor Type 1 (CBMolecules (Basel, Switzerland) · 2021Review
- Localization of cannabinoid and cannabinoid related receptors in the cat gastrointestinal tract.Histochemistry and cell biology · 2020Article
- CBPharmacology, biochemistry, and behavior · 2019Article
- Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract.Histochemistry and cell biology · 2018Article
- MAGL inhibition modulates gastric secretion and motility following NSAID exposure in mice.European journal of pharmacology · 2017Article
- Peripheral signals mediate the beneficial effects of gastric surgery in obesity.Gastroenterology research and practice · 2015Review
- Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss.Drug design, development and therapy · 2014Review
- Acute Δ(9)-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice.European journal of pharmacology · 2013Article
- Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice.The Journal of pharmacology and experimental therapeutics · 2011Article
- Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental data suggest that the endogenous cannabinoid system is involved in gastric function in different animal species. In most of them, CB(1) receptors have been localized on vagal terminals innervating the external wall of the stomach. We aimed at studying the putative presence and distribution of these receptors in the human gastric mucosa. To this end, we first performed Western blotting, RT-PCR, in situ hybridization, and immunohistochemical analysis of CB(1) protein distribution in biopsy samples of healthy individuals. To determine the precise cell populations expressing CB(1) receptors, we performed double immunofluorescence plus confocal microscopy analysis of the same samples. Our results show that CB(1) receptors are present in the gastric epithelium of the mucosa. Specifically, they are expressed by a subpopulation of mucosal cells, the acid-secreting parietal cells, as shown by double immunohistochemical staining and by their differential abundance in subregions of the gastric mucosa. These results reinforce the notion of a prominent role for the endocannabinoid system in the gastric function in humans and postulate the use of cannabinoid CB(1) receptors in parietal cells as new therapeutic targets for the regulation of gastric acid production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.