ArticleProceedings. Biological sciences2008
Self-referent MHC type matching in frog tadpoles.
Article in Proceedings. Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- Host-parasite coevolution and the stability of genetic kin recognition.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Olfaction across the water-air interface in anuran amphibians.Cell and tissue research · 2021Review
- Males optimally balance selfish and kin-selected strategies of sexual competition in the guppy.Nature ecology & evolution · 2020Article
- Article
- Social discrimination by quantitative assessment of immunogenetic similarity.Proceedings. Biological sciences · 2012Article
- Ecological immunogenetics of life-history traits in a model amphibian.Biology letters · 2012Article
- MHC signaling during social communication.Advances in experimental medicine and biology · 2012Article
- Association preference and mechanism of kin recognition in tadpoles of the toad Bufo melanostictus.Journal of biosciences · 2009Article
- The neuronal substrates of human olfactory based kin recognition.Human brain mapping · 2009Article
- Major histocompatibility complex based resistance to a common bacterial pathogen of amphibians.PloS one · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self/non-self recognition mechanisms underlie the development, immunology and social behaviour of virtually all living organisms, from bacteria to humans. Indeed, recognition processes lie at the core of how social cooperation evolved. Much evidence suggests that the major histocompatibility complex (MHC) both facilitates nepotistic interactions and promotes inbreeding avoidance. Social discrimination based on MHC differences has been demonstrated in many vertebrates but whether the labels used in discrimination are directly associated with the MHC, rather than with other genes with which it covaries, has remained problematic. Furthermore, effects of familiarity on natural preferences have not been controlled in most previous studies. Here we show that African clawed frog (Xenopus laevis) tadpoles discriminate among familiar full siblings based on MHC haplotype differences. Subjects (N=261) from four parental crosses preferred siblings with which they shared MHC haplotypes to those with no MHC haplotypes in common. Using only full siblings in experimental tests, we controlled for genetic variation elsewhere in the genome that might influence schooling preferences. As test subjects were equally familiar with stimulus groups, we conclude that tadpole discrimination involves a self-referent genetic recognition mechanism whereby individuals compare their own MHC type with those of conspecifics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.