Evidence map›Paper›PMID 18284246›Full record

ArticleOrganic letters2008

Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid.

Joanna Gajewiak, Ryoko Tsukahara, Yuko Fujiwara, Gabor Tigyi, Glenn D Prestwich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Synthetic Lipid Biology.Chemical reviews · 2025
    Review
  2. Elucidating the binding mechanism of LPA species and analogs in an LPAJournal of molecular graphics & modelling · 2022
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joanna GajewiakDepartment of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Salt Lake City, UT 84108-1257, USA.
Ryoko Tsukahara
Yuko Fujiwara
Gabor Tigyi
Glenn D Prestwich

Funding

Ligand Recognition by Phospholipid Growth Factor ReceptorsR01CA092160 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI TIGYI, GABOR J · 2001 to 2022
$5.9M
Phosphoinositide and Inositol Polyphosphate ProbesR01NS029632 · NINDS · UNIVERSITY OF UTAH · PI PRESTWICH, GLENN DOWNES · 1992 to 2007
$2.5M
THERAPEUTICALLY PROMISING PHOSPHOLIPID GROWTH FACTORSR01HL061469 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI TIGYI, GABOR J · 1999 to 2006
$2.0M
NCI NIH HHS CA 921160NCI NIH HHS R01 CA092160NHLBI NIH HHS HL 61469NHLBI NIH HHS R01 HL061469NINDS NIH HHS NS 29632NINDS NIH HHS R01 NS029632
6 · The paper itself

Abstract

An efficient enantioselective synthesis of sn-2-aminooxy (AO) analogues of lysophosphatidic acid (LPA) that possess palmitoyl and oleoyl acyl chains is presented. Both sn-2-AO LPA analogues are agonists for the LPA1, LPA2, and LPA4 G-protein-coupled receptors, but antagonists for the LPA3 receptor and inhibitors of autotaxin (ATX). Moreover, both analogues stimulate migration of intestinal epithelial cells in a scratch wound assay.

Indexed as

AnimalsCell Line, TumorCell MovementCHO CellsCricetinaeCricetulusLysophospholipase DLysophospholipidsMolecular StructureMultienzyme ComplexesPhosphodiesterase IPhosphoric Diester HydrolasesPyrophosphatasesRatsReceptors, Lysophosphatidic Acidlysophosphatidic acidLysophospholipase DLysophospholipidsMultienzyme ComplexesPhosphodiesterase IPhosphoric Diester HydrolasesPyrophosphatasesReceptors, Lysophosphatidic Acid

Identifiers

PMID18284246
PMCPMC3510981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.