ArticleVirchows Archiv : an international journal of pathology2008
Computer-assisted validation of the synovitis score.
Article in Virchows Archiv : an international journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis.Archives of orthopaedic and trauma surgery · 2022Article
- Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges.Arthritis research & therapy · 2022Review
- A convolutional neural network with transfer learning for automatic discrimination between low and high-grade synovitis: a pilot study.Internal and emergency medicine · 2021Article
- [Value of histological work-up for synovial diseases].Der Orthopade · 2009Review
- [Differential diagnosis of synovitis].Der Pathologe · 2008Article
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8 authors.
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Abstract
Histopathological examination of synovial specimens can contribute to the diagnosis of chronic joint diseases. A so-called synovitis score has been introduced as a standardised grading system, based on the semi-quantitative evaluation of the three determining features of chronic synovitis: enlargement of synovial lining, density of synovial stroma and inflammatory infiltrate, giving a score between 0 and 9. The present study examines the reliability of this procedure by comparison with exact measurements using computer-assisted image analysis (CAIA). Seventy-one synovial specimens from patients with osteoarthritis (OA, n=22), psoriatic arthritis (PsA, n=7), rheumatoid arthritis (RA, n=35) and from a control group (Co, n=7) were evaluated using both the synovitis score and CAIA. The measurements were transformed to semi-quantitative values analogous to the synovitis score. The differences between the transformed CAIA scores and the pathologist's scores were 0 or +/-1 in 40 cases, whereas in 31 cases the difference was greater than 1 (correlation coefficient r=0.725). The CAIA scores differed significantly between Co and RA cases (p=0.000) as well as between OA and RA (p=0.000). We conclude that the synovitis score was validated by CAIA and can be regarded a reliable grading system that contributes to the diagnostic procedure of chronic joint inflammation.
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