ArticleJournal of mathematical biology2009
Signaling cascades as cellular devices for spatial computations.
Article in Journal of mathematical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Proofreading through spatial gradients.eLife · 2020Article
- Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway.International journal of molecular sciences · 2019Review
- Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.PLoS computational biology · 2018Article
- Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions.Biophysical journal · 2018Review
- Spatial organization of the Ran pathway by microtubules in mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Intracellular regulation of cell signaling cascades: how location makes a difference.Journal of mathematical biology · 2014Article
- Dynamics and stability of a three-dimensional model of cell signal transduction.Journal of mathematical biology · 2013Article
- An investigation of spatial signal transduction in cellular networks.BMC systems biology · 2012Article
- A motor-driven mechanism for cell-length sensing.Cell reports · 2012Article
- Model of cell signal transduction in a three-dimensional domain.Journal of mathematical biology · 2011Article
- Formation of intracellular concentration landscapes by multisite protein modification.Biophysical journal · 2010Article
- Signalling ballet in space and time.Nature reviews. Molecular cell biology · 2010Review
- Spatially distributed cell signalling.FEBS letters · 2009Review
- Can molecular motors drive distance measurements in injured neurons?PLoS computational biology · 2009Article
- Positional information generated by spatially distributed signaling cascades.PLoS computational biology · 2009Article
- Signaling gradients in cascades of two-state reaction-diffusion systems.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Four-dimensional dynamics of MAPK information processing systems.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Signaling networks usually include protein-modification cycles. Cascades of such cycles are the backbones of multiple signaling pathways. Protein gradients emerge from the spatial separation of opposing enzymes, such as kinases and phosphatases, or guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) for GTPase cycles. We show that different diffusivities of an active protein form and an inactive form leads to spatial gradients of protein abundance in the cytoplasm. For a cascade of cycles, using a discrete approximation of the space, we derive an analytical expression for the spatial gradients and show that it converges to an exact solution with decreasing the size of the quantization. Our results facilitate quantitative analysis of the dependence of spatial gradients on the network topology and reaction kinetics. We demonstrate how different cascade designs filter and process the input information to generate precise, complex spatial guidance for multiple GTPase effector processes. Thus, protein-modification cascades may serve as devices to compute complex spatial distributions of target proteins within intracellular space.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.