ArticleIntensive care medicine2008
Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- PPARγ Regulates Macrophage Polarization by Inhibiting the JAK/STAT Pathway and Attenuates Myocardial Ischemia/Reperfusion Injury In Vivo.Cell biochemistry and biophysics · 2023Article
- Effects of adenosine N1-Oxide and pioglitazone on inflammatory and antioxidant state in sepsis caused by experimental cecal puncture in rat.Veterinary research forum : an international quarterly journal · 2023Article
- Potential benefits of metformin and pioglitazone combination therapy via gut microbiota and metabolites in high-fat diet-fed mice.Frontiers in pharmacology · 2022Article
- PPARγ in Ischemia-Reperfusion Injury: Overview of the Biology and Therapy.Frontiers in pharmacology · 2021Review
- Type 2 Diabetic Sepsis Patients Have a Lower Mortality Rate in Pioglitazone Use: A Nationwide 15-Year Propensity Score Matching Observational Study in Taiwan.Emergency medicine international · 2021Article
- Reassessment of Pioglitazone for Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Presence of the apolipoprotein E-ε4 allele is associated with an increased risk of sepsis progression.Scientific reports · 2020Article
- Lipid Use and Misuse by the Heart.Circulation research · 2016Review
- Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both?Current heart failure reports · 2015Review
- Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis.Innate immunity · 2014Article
- Endothelial cell peroxisome proliferator-activated receptor γ reduces endotoxemic pulmonary inflammation and injury.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections.PLoS pathogens · 2012Article
- Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice.Influenza and other respiratory viruses · 2010Article
- Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock.Intensive care medicine · 2010Article
- TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation.Intensive care medicine · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether peroxisome proliferator-activated receptor (PPAR) gamma ligands improve survival of patients with septic shock we treated a mouse model of sepsis [apolipoprotein (Apo) E) knockout mice] with pioglitazone, a PPAR-gamma ligand. ApoE knockout mice have a high mortality rate due to sepsis because the endotoxin is not cleared. DESIGN AND
settingProspective study in a university laboratory. SUBJECTS: We assorted 87 male ApoE knockout mice and 60 wild-type C57/B6 mice randomly into three groups (sepsis, pretreatment, posttreatment).
interventionsCecal ligation and puncture (CLP) was carried out in the sepsis and treatment groups. Mice were injected with pioglitazone (5 mg/kg per day) on the day before CLP or 6 h after surgery. MEASUREMENTS AND
resultsBoth pre- and post-CLP treatment with pioglitazone improved survival of ApoE knockout and wild-type mice. Serum levels of cytokines and chemokines and myeloperoxidase activity in lung and liver were suppressed in the pioglitazone-treated group. Pioglitazone also suppressed monocyte adhesion to vascular endothelium under flow conditions.
conclusionsPioglitazone improved survival of ApoE knockout mice after onset of septic shock through suppression of inflammatory responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.