ArticleJournal of neurology2008
A combined clinical and MRI approach for outcome assessment of traumatic head injured comatose patients.
Article in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Disorder of consciousness: Structural integrity of brain networks for the clinical assessment.Annals of clinical and translational neurology · 2023Article
- Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Post-Traumatic Comatose Patients.Brain sciences · 2020Article
- Disruption of the ascending arousal network in acute traumatic disorders of consciousness.Neurology · 2019Article
- Could Arterial Spin Labeling Distinguish Patients in Minimally Conscious State from Patients in Vegetative State?Frontiers in neurology · 2018Article
- Revisiting Grade 3 Diffuse Axonal Injury: Not All Brainstem Microbleeds are Prognostically Equal.Neurocritical care · 2017Article
- Deceased organ donation for transplantation: Challenges and opportunities.World journal of transplantation · 2016Article
- Predicting Outcome after Pediatric Traumatic Brain Injury by Early Magnetic Resonance Imaging Lesion Location and Volume.Journal of neurotrauma · 2016Article
- Neuroanatomical basis of paroxysmal sympathetic hyperactivity: a diffusion tensor imaging analysis.Brain injury · 2015Article
- The prognostic reliability of the Glasgow coma score in traumatic brain injuries: evaluation of MRI data.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2013Article
- Severe traumatic head injury: prognostic value of brain stem injuries detected at MRI.AJNR. American journal of neuroradiology · 2012Article
- Prediction of outcome after traumatic brain injury using clinical and neuroimaging variables.Journal of clinical neurology (Seoul, Korea) · 2012Article
- Mindsight: diagnostics in disorders of consciousness.Critical care research and practice · 2012Article
- Neuroimaging after coma.Neuroradiology · 2010Review
- Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: a diffusion tensor imaging study using voxel-based approaches.Human brain mapping · 2009Article
- Clinical review: Prognostic value of magnetic resonance imaging in acute brain injury and coma.Critical care (London, England) · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledTraumatic brain injury (TBI) is associated with substantial consumption of health care resources. No clinical or paraclinical examination can reliably predict neurological evolution. In this study, we evaluated the ability of a combined clinical and MRI approach to predict outcome.
methodsThis prospective study took place between June 2001 and March 2005 in a Neurosurgical Intensive Care Unit in Paris, France. Inclusion criteria were TBI patients still mechanically ventilated and without clinical signs of awareness after 2 weeks. Four clinical signs were assessed after cessation of sedation: grasping, yawning, chewing and paroxysmal sympathetic storm. FLAIR and T2* acquisitions on MRI were used in order to localize brain lesions. Statistically linked regions (clusters) were defined. Outcome was assessed at one year by Glasgow Outcome Scale (GOS).
findings73 patients were included: 41 had poor outcome (GOS 1-3) and 32 had good outcome (GOS 4-5). Lesions in the clusters "right upper pons and right lower midbrain"," hypothalamus and basal forebrain","left parietal, left temporal, left occipital lobes and left insula" and the presence of grasping or chewing were associated with poor outcome in multivariate analysis. This combined clinical and MRI approach gives a much better prediction than MRI approach only (P < 0.009), with an area under the ROC curve of 0.94 (95 % CI, 0.89-1.00).
interpretationThese data suggest that MRI associated with clinical assessment improves outcome prediction in severe TBI patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.