Evidence map›Paper›PMID 18283324›Full record

ReviewBritish journal of cancer2008

Approaches to working in high-dimensional data spaces: gene expression microarrays.

Y Wang, D J Miller, R Clarke

Abstract readReview
In one paragraph

Review in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Study design in high-dimensional classification analysis.Biostatistics (Oxford, England) · 2016
    Article
  14. Parallel classification and feature selection in microarray data using SPRINT.Concurrency and computation : practice & experience · 2014
    Article
  15. Review
  16. Article
  17. Review
  18. Antiestrogen Resistance and the Application of Systems Biology.Drug discovery today. Disease mechanisms · 2012
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Y WangDepartment of Electrical, Computer, and Biomedical Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA. yuewang@vt.edu
D J Miller
R Clarke

Funding

Molecular Analysis of Human Breast CancerR01CA096483 · NCI · GEORGETOWN UNIVERSITY · PI CLARKE, ROBERT R. · 2003 to 2007
$2.5M
Compute Decomposition/Composite Molecular SignaturesR33EB000830 · NIBIB · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, YUE · 2005 to 2007
$1.6M
Comprehensive Analysis of Microarray Gene ExpressionR33CA109872 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, YUE · 2005 to 2007
$1.4M
Compute Decomposition/Composite Molecular SignaturesR21EB000830 · NIBIB · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, YUE · 2003 to 2004
$266k
Comprehensive Analysis of Microarray Gene ExpressionR21CA109872 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, YUE · 2004 to 2004
$149k
NCI NIH HHS CA096483NCI NIH HHS CA109872NCI NIH HHS R01 CA096483NCI NIH HHS R21 CA109872NCI NIH HHS R33 CA109872NIBIB NIH HHS EB000830NIBIB NIH HHS R21 EB000830NIBIB NIH HHS R33 EB000830
6 · The paper itself

Abstract

This review provides a focused summary of the implications of high-dimensional data spaces produced by gene expression microarrays for building better models of cancer diagnosis, prognosis, and therapeutics. We identify the unique challenges posed by high dimensionality to highlight methodological problems and discuss recent methods in predictive classification, unsupervised subclass discovery, and marker identification.

Indexed as

Computational BiologyBiomarkers, TumorGene Expression ProfilingMicroarray AnalysisModels, StatisticalNeoplasmsBiomarkers, Tumor

Identifiers

PMID18283324
PMCPMC2275474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.