ArticleJournal of virology1991
Role of E2F transcription factor in E1A-mediated trans activation of cellular genes.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 140 citations in OpenAlex.
- Article
- TFDP3 as E2F Unique Partner, Has Crucial Roles in Cancer Cells and Testis.Frontiers in oncology · 2021Review
- Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data.BMC bioinformatics · 2014Article
- The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription.Journal of virology · 2013Article
- E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity.International journal of biological sciences · 2010Article
- Article
- E2F is required to prevent inappropriate S-phase entry of mammalian cells.Molecular and cellular biology · 2000Article
- The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.Molecular and cellular biology · 1998Article
- Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins.Molecular and cellular biology · 1997Article
- Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms.Molecular and cellular biology · 1997Article
- Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F.Molecular and cellular biology · 1996Article
- Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis.Journal of virology · 1996Article
- E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.Molecular and cellular biology · 1995Article
- Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription.Journal of virology · 1995Article
- Activation of a retinoblastoma-protein-dependent pathway by sphingosine.The Biochemical journal · 1995Article
- In vivo association of E2F and DP family proteins.Molecular and cellular biology · 1995Article
- Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines.The Journal of clinical investigation · 1995Article
- The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.Molecular and cellular biology · 1995Article
- The transcription factor E2F-1 is a downstream target of RB action.Molecular and cellular biology · 1995Article
- Reciprocal regulation of the Epstein-Barr virus BamHI-F promoter by EBNA-1 and an E2F transcription factor.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Adenovirus E1A-dependent trans activation of the adenovirus E2 gene involves the activation of the cellular transcription factor E2F. E2F binding sites have also been identified in the 5'-flanking region of a number of cellular genes, raising the possibility that such genes are targets for E1A trans activation. We now demonstrate that two genes that possess E2F recognition sites, N-myc and DHFR, are stimulated by E1A, dependent on the E2F sites. We also find that although there are multiple E2F sites in these promoters, a single intact E2F binding site is sufficient for E1A-mediated induction, although not to the full wild-type level. These results thus demonstrate that a variety of cellular genes that possess E2F binding sites are subject to E1A trans activation. Moreover, since the products of most of these genes are likely critical for cellular proliferation, there are obvious consequences of this trans activation for cellular phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.