ReviewCurrent opinion in genetics & development2008
Microenvironmental regulation of cancer development.
Review in Current opinion in genetics & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 334 citations in OpenAlex.
- Development and validation of a prognostic model based on T cell signature genes in colon cancer using single-cell RNA sequencing.Clinical and experimental medicine · 2026Article
- Phyllodes-predominant prostatic stromal sarcoma concurrent with prostate adenocarcinoma: a case report and literature review.Frontiers in oncology · 2026Article
- Collagen type I alpha 1 induces radio-resistance in hypoxic glioblastoma cells by promoting autophagy.Journal of neuro-oncology · 2025Article
- Review
- Harnessing agent-based frameworks in CellAgentChat to unravel cell-cell interactions from single-cell and spatial transcriptomics.Genome research · 2025Article
- Review
- VGAE-CCI: variational graph autoencoder-based construction of 3D spatial cell-cell communication network.Briefings in bioinformatics · 2024Article
- The Novel Fusion Protein Melittin-MIL-2 Exhibits Strong Antitumor Immune Effect in Lung Adenocarcinoma Cell A549.The clinical respiratory journal · 2024Article
- Role of stromal PD-L1 expression in colorectal liver metastasis.BMC cancer · 2024Article
- Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies.NPJ precision oncology · 2023Article
- M2 macrophage-secreted exosomes promote metastasis and increase vascular permeability in hepatocellular carcinoma.Cell communication and signaling : CCS · 2023Article
- Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases.Genes & diseases · 2023Review
- M6A RNA methylation modification and tumor immune microenvironment in lung adenocarcinoma.Biophysics reports · 2023Article
- The Variety of 3D Breast Cancer Models for the Study of Tumor Physiology and Drug Screening.International journal of molecular sciences · 2023Review
- Review
- Integrative bioinformatics approaches to establish potential prognostic immune-related genes signature and drugs in the non-small cell lung cancer microenvironment.Frontiers in pharmacology · 2023Article
- EMT and Tumor Turning Point Analysis in 3D Spheroid Culture of HNSCC and Mesenchymal Stem Cells.Biomedicines · 2022Article
- A novel prognostic model for cutaneous melanoma based on an immune-related gene signature and clinical variables.Scientific reports · 2022Article
- Evaluation of cell-cell interaction methods by integrating single-cell RNA sequencing data with spatial information.Genome biology · 2022Article
- Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells.Cell death & disease · 2022Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous studies have demonstrated that the tumor microenvironment not only responds to and supports carcinogenesis, but also actively contributes to tumor initiation, progression, and metastasis. During tumor progression all cells composing the tumor undergo phenotypic and epigenetic changes. Paracrine signaling between epithelial and stromal cells is important for the regulation of the proliferation, invasive, angiogenic, and metastatic behavior of cancer cells. Better understanding the molecular mechanisms by which stromal cells exert these effects may open up new venues for cancer therapeutic and preventative interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.