ArticleCell calcium2008
Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?
Article in Cell calcium, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- The multifaceted role of mitochondria in cardiac function: insights and approaches.Cell communication and signaling : CCS · 2024Review
- Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome.Frontiers in medicine · 2023Review
- Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases.International journal of molecular sciences · 2022Review
- Genetic variation in satiety signaling and hypothalamic inflammation: merging fields for the study of obesity.The Journal of nutritional biochemistry · 2022Review
- Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling.International journal of molecular sciences · 2022Review
- Adaptive mitochondrial response of the whiteleg shrimp Litopenaeus vannamei to environmental challenges and pathogens.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice.Journal of the American Heart Association · 2019Article
- The role of the mitochondrial calcium uniporter (MCU) complex in cancer.Pflugers Archiv : European journal of physiology · 2018Review
- Different approaches to modeling analysis of mitochondrial swelling.Mitochondrion · 2018Review
- Muscle Non-shivering Thermogenesis and Its Role in the Evolution of Endothermy.Frontiers in physiology · 2017Review
- Mitochondrial calcium transport in trypanosomes.Molecular and biochemical parasitology · 2014Review
- Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.Basic research in cardiology · 2014Article
- NCLX: the mitochondrial sodium calcium exchanger.Journal of molecular and cellular cardiology · 2013Article
- Glutaredoxin-2 is required to control proton leak through uncoupling protein-3.The Journal of biological chemistry · 2013Article
- Article
- Endothelial mitochondria--less respiration, more integration.Pflugers Archiv : European journal of physiology · 2012Review
- Ca2+ dynamics in the mitochondria - state of the art.Journal of molecular and cellular cardiology · 2011Article
- Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The underlying molecular action of the novel uncoupling proteins 2 and 3 (UCP2 and UCP3) is still under debate. The proteins have been implicated in many cell functions, including the regulation of insulin secretion and regulation of reactive oxygen species (ROS) generation. These effects have mainly been explained by suggesting that the proteins establish a proton leak through the inner mitochondrial membrane (IMM). However, accumulating data question this mechanism and suggest that UCP2 and UCP3 may play other roles, including carrying free fatty acids from the matrix towards the intermembrane space, or contributing to the mitochondrial Ca(2+) uniport. Accordingly, in this review we reflect on these actions of UCP2/UCP3 and discuss alternative explanations for the molecular mechanisms by which UCP2/UCP3 might contribute to aspects of cell function. Based on the potential role of UCP2/UCP3 in regulating mitochondrial Ca(2+) uptake, we propose a scheme whereby these proteins integrate Ca(2+)-dependent signal transduction and energy metabolism in order to meet the energy demand of the cell for its continuous response, adaptation, and stimulation to environmental input.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.