ReviewAdvances in genetics2008
Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis.
Review in Advances in genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Phylogeny and Molecular Characterisation ofBrain sciences · 2025Article
- SArKS: de novo discovery of gene expression regulatory motif sites and domains by suffix array kernel smoothing.Bioinformatics (Oxford, England) · 2019Article
- Zebrafish: A Powerful Model for Understanding the Functional Relevance of Noncoding Region Mutations in Human Genetic Diseases.Biomedicines · 2019Review
- Sequence based prediction of enhancer regions from DNA random walk.Scientific reports · 2018Article
- Distribution of Initiation Times Reveals Mechanisms of Transcriptional Regulation in Single Cells.Biophysical journal · 2018Article
- Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells.Biology of sex differences · 2017Article
- In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.Drug metabolism and disposition: the biological fate of chemicals · 2017Article
- The most common technologies and tools for functional genome analysis.Acta medica Lituanic · 2017Article
- Transcriptional Interference Promotes Rapid Expression Divergence of Drosophila Nested Genes.Genome biology and evolution · 2016Article
- Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences.Human genetics · 2014Review
- Article
- Generation and application of signaling pathway reporter lines in zebrafish.Molecular genetics and genomics : MGG · 2013Review
- Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia.Basic research in cardiology · 2013Article
- New advances in the genetic basis of atrial fibrillation.Journal of cardiovascular electrophysiology · 2012Review
- An embryonic stem cell-based system for rapid analysis of transcriptional enhancers.Genesis (New York, N.Y. : 2000) · 2012Article
- Article
- Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway.Breast cancer research : BCR · 2011Article
- Article
- Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study.BMC medical genetics · 2010Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Despite remarkable recent advances in genomics that have enabled us to identify most of the genes in the human genome, comparable efforts to define transcriptional cis-regulatory elements that control gene expression are lagging behind. The difficulty of this task stems from two equally important problems: our knowledge of how regulatory elements are encoded in genomes remains elementary, and there is a vast genomic search space for regulatory elements, since most of mammalian genomes are noncoding. Comparative genomic approaches are having a remarkable impact on the study of transcriptional regulation in eukaryotes and currently represent the most efficient and reliable methods of predicting noncoding sequences likely to control the patterns of gene expression. By subjecting eukaryotic genomic sequences to computational comparisons and subsequent experimentation, we are inching our way toward a more comprehensive catalog of common regulatory motifs that lie behind fundamental biological processes. We are still far from comprehending how the transcriptional regulatory code is encrypted in the human genome and providing an initial global view of regulatory gene networks, but collectively, the continued development of comparative and experimental approaches will rapidly expand our knowledge of the transcriptional regulome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.