ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic Dissection of Femoral and Tibial Microarchitecture.JBMR plus · 2019Article
- Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.PLoS genetics · 2016Article
- Article
- Genetic regulation of bone strength: a review of animal model studies.BoneKEy reports · 2015Review
- High-resolution genome screen for bone mineral density in heterogeneous stock rat.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility.Bone · 2011Article
- Article
- Article
- Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck.Physiological genomics · 2008Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionHip fracture is the most devastating osteoporotic fracture type with significant morbidity and mortality. Several studies in humans identified chromosomal regions linked to hip size and bone mass. Animal models, particularly the inbred rat, serve as complementary approaches for studying the genetic influence on hip fragility. The purpose of this study is to identify sex-independent and sex-specific quantitative trait loci (QTLs) for femoral neck density, structure, and strength in inbred Copenhagen 2331 (COP) and Dark Agouti (DA) rats. MATERIALS AND
methodsA total of 828 (405 males and 423 females) F(2) progeny derived from the inbred COP and DA strains of rats were phenotyped for femoral neck volumetric BMD (vBMD), cross-sectional area, polar moment of inertia (Ip), neck width, ultimate force, and energy to break. A whole genome screen was performed using 93 microsatellite markers with an average intermarker distance of 20 cM. Recombination-based marker maps were generated using MAPMAKER/EXP from the COP x DA F(2) data and compared with published Rat Genome Database (RGD) maps. These maps were used for genome-wide linkage analyses to detect sex-independent and sex-specific QTLs.
resultsSignificant evidence of linkage (p < 0.01) for sex-independent QTLs were detected for (1) femoral neck vBMD on chromosomes (Chrs) 1, 6, 10, and 12, (2) femoral neck structure on Chrs 5, 7, 10, and 18, and (3) biomechanical properties on Chrs 1 and 4. Male-specific QTLs were discovered on Chrs 2, 9, and 18 for total vBMD, on Chr 17 for trabecular vBMD, on Chr 9 for total bone area, and on Chr 15 for ultimate force. A female-specific QTL was discovered on Chr 2 for ultimate force. The effect size of the individual QTL varied between 1% and 4%.
conclusionsWe detected evidence that sex-independent and sex-specific QTLs contribute to hip fragility in the inbred rat. Several QTLs regions identified in this study are homologous to human chromosomal regions previously linked to QTLs contributing to femoral neck and related phenotypes.
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