ArticlePLoS pathogens2008
Nanobacteria are mineralo fetuin complexes.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Clinical implications of calcifying nanoparticles in dental diseases: a critical review.International journal of nanomedicine · 2014Pooled it
- Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids.The Journal of biological chemistry · 2013Trial
- Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cellsWorld journal of stem cells · 2025Article
- Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Femtoplankton: What's New?Viruses · 2020Review
- Waiting for Aπαταω: 250 Years Later.Foundations of science · 2019Article
- Calcifying nanoparticles induce cytotoxicity mediated by ROS-JNK signaling pathways.Urolithiasis · 2019Article
- Discovery of High Abundances of Aster-Like Nanoparticles in Pelagic Environments: Characterization and Dynamics.Frontiers in microbiology · 2019Article
- Formation and characteristics of biomimetic mineralo-organic particles in natural surface water.Scientific reports · 2016Article
- Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions.Scientific reports · 2016Article
- Pleomorphic Structures in Human Blood Are Red Blood Cell-Derived Microparticles, Not Bacteria.PloS one · 2016Article
- Viruses Occur Incorporated in Biogenic High-Mg Calcite from Hypersaline Microbial Mats.PloS one · 2015Article
- Renal struvite stones--pathogenesis, microbiology, and management strategies.Nature reviews. Urology · 2014Review
- Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells.Nanoscale research letters · 2014Article
- Calcifying nanoparticles promote mineralization in vascular smooth muscle cells: implications for atherosclerosis.International journal of nanomedicine · 2014Article
- Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells.International journal of nanomedicine · 2014Article
- A phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease.Kidney international supplements · 2013Review
- Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.PloS one · 2013Article
- Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice.PloS one · 2012Article
- The role of calcifying nanoparticles in biology and medicine.International journal of nanomedicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Nanobacteria" are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged by both geologists and microbiologists, with opinions ranging from considering them crystal structures to new life forms. Although the nature of these autonomously replicating particles is still under debate, their role in several calcification-related diseases has been reported. In order to gain better insights on this calciferous agent, we performed a large-scale project, including the analysis of "nanobacteria" susceptibility to physical and chemical compounds as well as the comprehensive nucleotide, biochemical, proteomic, and antigenic analysis of these particles. Our results definitively ruled out the existence of "nanobacteria" as living organisms and pointed out the paradoxical role of fetuin (an anti-mineralization protein) in the formation of these self-propagating mineral complexes which we propose to call "nanons." The presence of fetuin within renal calculi was also evidenced, suggesting its role as a hydroxyapatite nucleating factor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.