Evidence map›Paper›PMID 18281860›Full record

ReviewCurrent opinion in rheumatology2008

The spectrum of autoinflammatory diseases: recent bench to bedside observations.

John G Ryan, Raphaela Goldbach-Mansky

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in rheumatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Alcohol accumulation promotes esophagitis via pyroptosis activation.International journal of biological sciences · 2018
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Cryopyrin-associated periodic syndromes: otolaryngologic and audiologic manifestations.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2011
    Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John G RyanGenetics and Genomics Branch, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Raphaela Goldbach-Mansky
National Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

Pathogenesis and treatment studies in patients with NOMID and related diseasesZIAAR041138 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2009 to 2016
$8.6M
Pathogenesis and treatment studies in patients with NOMID and related diseasesZ01AR041138 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2003 to 2008
$2.3M
Intramural NIH HHS ZIA AR041138
6 · The paper itself

Abstract

purpose of reviewThe autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious danger signals. This article focuses on recent progress in our understanding of autoinflammatory syndromes, and how insights into these conditions have triggered the exploration of the role of innate immunity in common rheumatologic diseases. RECENT

findingsNew models for the pathogenesis of several autoinflammatory syndromes have been proposed, including the role of pyrin and cryopyrin in regulating inflammation. Robust evidence has emerged that IL-1beta oversecretion is pivotal in cryopyrin-associated periodic syndromes, and that IL-1 inhibition ameliorates the clinical features of these syndromes. Monosodium urate crystals stimulate IL-1beta secretion via cryopyrin, which led to the addition of gout to the spectrum of autoinflammatory diseases. SUMMARY: Advances in our understanding of the autoinflammatory diseases have led to renewed interest in the innate immune system, and its role in the pathogenesis of more common rheumatic diseases.

Indexed as

FeverAutoimmune DiseasesCarrier ProteinsCytoskeletal ProteinsGenetic Diseases, InbornHumansInflammationNLR Family, Pyrin Domain-Containing 3 ProteinPyrinCarrier ProteinsCytoskeletal ProteinsMEFV protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPyrin

Identifiers

PMID18281860
PMCPMC4565798
OpenAlexW2048551300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.