ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2008
Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer.
Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 288 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
288 citing papers in PubMed, 11 syntheses or guidelines pooled it, 598 citations in OpenAlex.
- Which specific modes of exercise training are most effective for breast related cancer fatigue? Network meta-analysis.Frontiers in oncology · 2025Pooled it
- Cognitive impairment following breast cancer treatments: an umbrella review.The oncologist · 2024Pooled it
- Chemotherapy-induced cognitive impairment in breast cancer survivors: A systematic review of studies from 2000 to 2021.Cancer reports (Hoboken, N.J.) · 2024Pooled it
- Bibliometric and visualization analyses of cancer-related fatigue research published worldwide from 2001 to 2023.Frontiers in oncology · 2024Pooled it
- Acupuncture and moxibustion for malignant tumor patients with psychological symptoms of insomnia, anxiety and depression: a systematic review and Meta-analysis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Pooled it
- Cancer-related inflammation and depressive symptoms: Systematic review and meta-analysis.Cancer · 2022Pooled it
- Ameliorative effects of Tai Chi on cancer-related fatigue: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- Modifiable factors and cognitive dysfunction in breast cancer survivors: a mixed-method systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Pooled it
- Cancer-Related Fatigue, Version 2.2015.Journal of the National Comprehensive Cancer Network : JNCCN · 2015Guideline
- Survivorship: fatigue, version 1.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014Guideline
- Recommendations for high-priority research on cancer-related fatigue in children and adults.Journal of the National Cancer Institute · 2013Guideline
- Impact of a Functional Intervention with Home Follow-Up on Respiratory Symptoms and Functionality in Oncology Patients: A Randomised Clinical Trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Bilateral transcutaneous auricular vagus nerve stimulation for the treatment of insomnia in breast cancer.Scientific reports · 2025Trial
- Trial
- Qualitative similarities and distinctions between participants' experiences with a yoga intervention and an attention control.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Trial
- Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue.Scientific reports · 2023Trial
- Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes.Journal of the National Cancer Institute · 2023Trial
- A Randomized Controlled Pilot Study of Yoga Skills Training Versus an Attention Control Delivered During Chemotherapy Administration.Journal of pain and symptom management · 2022Trial
- Hyperarousal and Insomnia in Survivors of Cancer.International journal of behavioral medicine · 2021Trial
- Yoga therapy to reduce fatigue in cancer: effects of reminder e-mails and long-term efficacy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
228 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Patients with cancer experience a host of behavioral alterations that include depression, fatigue, sleep disturbances, and cognitive dysfunction. These behavioral comorbidities are apparent throughout the process of diagnosis and treatment for cancer and can persist well into the survivorship period. There is a rich literature describing potential consequences of behavioral comorbidities in patients with cancer including impaired quality of life, reduced treatment adherence, and increased disease-related morbidity and mortality. Medical complications of cancer and its treatment such as anemia, thyroid dysfunction, and the neurotoxicity of cancer chemotherapeutic agents account in part for these behavioral changes. Nevertheless, recent advances in the neurosciences and immunology/oncology have revealed novel insights into additional pathophysiologic mechanisms that may significantly contribute to the development of cancer-related behavioral changes. Special attention has been focused on immunologic processes, specifically activation of innate immune inflammatory responses and their regulation by neuroendocrine pathways, which, in turn, influence CNS functions including neurotransmitter metabolism, neuropeptide function, sleep-wake cycles, regional brain activity, and, ultimately, behavior. Further understanding of these immunologic influences on the brain provides a novel conceptual framework for integrating the wide spectrum of behavioral alterations that occur in cancer patients and may reveal a more focused array of translational targets for therapeutic interventions and future research. Such developments warrant complementary advances in identification of cancer patients at risk as well as those currently suffering, including an increased emphasis on the status of behavior as a "sixth vital sign" to be assessed in all cancer patients throughout their disease encounter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.