ArticleEukaryotic cell2008
An internal polarity landmark is important for externally induced hyphal behaviors in Candida albicans.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Looking outside the box: a comparative cross-kingdom view on the cell biology of the three major lineages of eukaryotic multicellular life.Cellular and molecular life sciences : CMLS · 2023Review
- Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans.Cellular microbiology · 2021Article
- Article
- Regulation ofJournal of fungi (Basel, Switzerland) · 2019Review
- Candida albicans Hyphae: From Growth Initiation to Invasion.Journal of fungi (Basel, Switzerland) · 2018Review
- The Transcriptional Response ofG3 (Bethesda, Md.) · 2017Article
- Cell Polarity in Yeast.Annual review of cell and developmental biology · 2017Review
- Sfp1 and Rtg3 reciprocally modulate carbon source-conditional stress adaptation in the pathogenic yeast Candida albicans.Molecular microbiology · 2017Article
- Thigmo Responses: The Fungal Sense of Touch.Microbiology spectrum · 2017Review
- Article
- Article
- Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.Journal of microbiology (Seoul, Korea) · 2016Review
- High frame-rate resolution of cell division during Candida albicans filamentation.Fungal genetics and biology : FG & B · 2016Article
- Candida-streptococcal mucosal biofilms display distinct structural and virulence characteristics depending on growth conditions and hyphal morphotypes.Molecular oral microbiology · 2015Article
- Contact-induced apical asymmetry drives the thigmotropic responses of Candida albicans hyphae.Cellular microbiology · 2015Article
- Distinct roles of Candida albicans-specific genes in host-pathogen interactions.Eukaryotic cell · 2014Article
- Dissecting the Molecular Mechanisms of Electrotactic Effects.Advances in wound care · 2014Review
- Cdc42 GTPase dynamics control directional growth responses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Rax2 is important for directional establishment of growth sites, but not for reorientation of growth axes, during Candida albicans hyphal morphogenesis.Fungal genetics and biology : FG & B · 2013Article
- Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.Eukaryotic cell · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Directional growth is a function of polarized cells such as neurites, pollen tubes, and fungal hyphae. Correct orientation of the extending cell tip depends on signaling pathways and effectors that mediate asymmetric responses to specific environmental cues. In the hyphal form of the eukaryotic fungal pathogen Candida albicans, these responses include thigmotropism and galvanotropism (hyphal turning in response to changes in substrate topography and imposed electrical fields, respectively) and penetration into semisolid substrates. During vegetative growth in C. albicans, as in the model yeast Saccharomyces cerevisiae, the Ras-like GTPase Rsr1 mediates internal cellular cues to position new buds in a prespecified pattern on the mother cell cortex. Here, we demonstrate that Rsr1 is also important for hyphal tip orientation in response to the external environmental cues that induce thigmotropic and galvanotropic growth. In addition, Rsr1 is involved in hyphal interactions with epithelial cells in vitro and its deletion diminishes the hyphal invasion of kidney tissue during systemic infection. Thus, Rsr1, an internal polarity landmark in yeast, is also involved in polarized growth responses to asymmetric environmental signals, a paradigm that is different from that described for the homologous protein in S. cerevisiae. Rsr1 may thereby contribute to the pathogenesis of C. albicans infections by influencing hyphal tip responses triggered by interaction with host tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.