Evidence map›Paper›PMID 18281599›Full record

ArticleEukaryotic cell2008

Evidence of a continuous endoplasmic reticulum in the protozoan parasite Entamoeba histolytica.

Jose E Teixeira, Christopher D Huston

Open access · diamondAbstract read
In one paragraph

Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. The history of entamoebiasis.Parasitology · 2025
    Review
  2. Evolution of factors shaping the endoplasmic reticulum.Traffic (Copenhagen, Denmark) · 2022
    Article
  3. Article
  4. Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives onFrontiers in cellular and infection microbiology · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. AnGenes · 2019
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jose E TeixeiraDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Christopher D Huston
University of Vermont · US

Funding

VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D · 2006 to 2011
$14.5M
Molecular Mechanism of Entamoeba histolytica phagocytosisR01AI072021 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D · 2008 to 2012
$1.6M
E. histolytica phagocytosis of apoptotic host cellsK08AI053678 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D · 2003 to 2007
$649k
NCRR NIH HHS P20 RR021905NIAID NIH HHS K08 AI053678NIAID NIH HHS R01 AI072021
6 · The paper itself

Abstract

Entamoeba histolytica, the cause of amebiasis, is believed to have no continuous endoplasmic reticulum (ER), with ER functions occurring in vesicles. Here, using an ER-targeted green fluorescent protein fusion protein and fluorescence loss in photobleaching, we have unambiguously demonstrated the presence of a continuous ER compartment in living E. histolytica trophozoites.

Indexed as

AnimalsEndoplasmic ReticulumEntamoeba histolyticaEntamoebiasisGreen Fluorescent ProteinsHumansPhotobleachingProtein TransportProtozoan ProteinsRecombinant Fusion ProteinsGreen Fluorescent ProteinsProtozoan ProteinsRecombinant Fusion Proteins

Identifiers

PMID18281599
PMCPMC2446670
OpenAlexW2110870833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.