ArticleSchizophrenia bulletin2009
Worth the risk? Relationship of incentives to risk and benefit perceptions and willingness to participate in schizophrenia research.
Article in Schizophrenia bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The Tobacco Status Project (TSP): Study protocol for a randomized controlled trial of a Facebook smoking cessation intervention for young adults.BMC public health · 2015Trial
- Does incentivising pill-taking 'crowd out' risk-information processing? Evidence from a web-based experiment.Social science & medicine (1982) · 2014Trial
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
- Comprehension of informed consent and voluntary participation in registration cohorts for phase IIb HIV vaccine trial in Dar Es Salaam, Tanzania: a qualitative descriptive study.BMC medical ethics · 2024Article
- Impact of financial compensation on enrollment and participation in a remote, mobile-app based research study.Journal of clinical and translational science · 2024Article
- Self-reported influences on willingness to receive COVID-19 vaccines among physically ill, mentally ill, and healthy individuals.Journal of psychiatric research · 2022Article
- Maternal Perceptions of Safeguards for Research Involving Children.Journal of child and family studies · 2022Article
- Factors Influencing Perceived Helpfulness and Participation in Innovative Research: A Pilot Study of Individuals with and without Mood Symptoms.Ethics & behavior · 2022Article
- Attitudes of Mothers Regarding Willingness to Enroll Their Children in Research.Journal of empirical research on human research ethics : JERHRE · 2020Article
- Negative association of perceived risk and willingness to participate in innovative psychiatric research protocols.Journal of psychiatric research · 2020Article
- Randomized evaluation of trial acceptability by INcentive (RETAIN): Study protocol for two embedded randomized controlled trials.Contemporary clinical trials · 2019Article
- Is It Worth It? Benefits in Research With Adults With Intellectual Disability.Intellectual and developmental disabilities · 2016Article
- Typologies of Altruistic and Financial Motivations for Research Participation.Journal of empirical research on human research ethics : JERHRE · 2016Article
- Article
- Bioethical Issues in Providing Financial Incentives to Research Participants.Medicolegal and bioethics · 2015Article
- Addressing risks to advance mental health research.JAMA psychiatry · 2013Article
- Incentives for research participation: policy and practice from Canadian corrections.American journal of public health · 2012Article
- Screening for understanding of research in the inpatient psychiatry setting.Journal of empirical research on human research ethics : JERHRE · 2011Article
- Ethics in Psychiatric Research: A Review of 25 Years of NIH-funded Empirical Research Projects.AJOB primary research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveProviding incentives for research participation is widely practiced but minimally studied. In schizophrenia research, questions about capacity to consent and potential vulnerability may raise concerns when offering incentives for participation. Despite empirical attention focused on consent and decision-making capacity in schizophrenia, the issue of incentives has been essentially ignored. We examined willingness to participate in research, in relation to perceived risks and benefits, among people with schizophrenia and schizoaffective disorder.
methodForty-six people with schizophrenia or schizoaffective disorder rated perceived risks and benefits of 5 hypothetical research vignettes. They also indicated whether they would be willing to participate at each of 5 incentive levels (including no compensation). Cognition was assessed with Mattis Dementia Rating Scale.
resultsRatings of risk and potential personal benefit were inversely correlated. For all scenarios, significant correlations were found between perceived risk and willingness to participate for greater compensation. Conversely, lower perceived likelihood of benefit was associated with a higher compensation threshold for participation in each scenario. Even at the highest proffered payment level for each scenario, however, a substantial proportion of respondents were not willing to participate. Risk assessment and willingness to participate (at all levels of compensation) were not associated with demographic variables or cognitive status.
conclusionsDetermining whether incentives impede voluntarism remains an important task for empirical ethics research. Assessing potential research participants' understanding and perceptions of risks, benefits, and alternatives to participation will help ensure that informed consent fulfills its mission--embodying the ethical principle of respect for persons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.