Evidence map›Paper›PMID 18281210›Full record

ReviewCurrent opinion in structural biology2008

Molecular dynamics simulations of nucleic acid-protein complexes.

Alexander D Mackerell, Lennart Nilsson

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 169 citations in OpenAlex.

  1. Review
  2. Article
  3. On the common pathways of deformation: RNA vs DNA under interrogation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Article
  6. Review
  7. Characterization of epitranscriptome reader proteins experimentally andComputational and structural biotechnology journal · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Revealing atomic-scale molecular diffusion of a plant-transcription factor WRKY domain protein along DNA.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Atomistic Analysis of ToxN and ToxI Complex Unbinding Mechanism.International journal of molecular sciences · 2018
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Alexander D MackerellDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA. Lennart.Nilsson@biosci.ki.se
Lennart Nilsson
Karolinska Institutet · SEUniversity of Maryland, Baltimore · US

Funding

Oligonucleotide Conformational HeterogeneityR01GM051501 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI MACKERELL, ALEXANDER D · 2003 to 2018
$3.6M
HALOGEN FREE ENERGY DATABASE FOR RATIONAL DRUG DESIGNR29GM051501 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI MACKERELL, ALEXANDER D. · 1996 to 2000
$108k
NIGMS NIH HHS GM051501NIGMS NIH HHS R01 GM051501NIGMS NIH HHS R29 GM051501
6 · The paper itself

Abstract

Molecular dynamics simulation studies of protein-nucleic acid complexes are more complicated than studies of either component alone-the force field has to be properly balanced, the systems tend to become very large, and a careful treatment of solvent and of electrostatic interactions is necessary. Recent investigations into several protein-DNA and protein-RNA systems have shown the feasibility of the simulation approach, yielding results of biological interest not readily accessible to experimental methods.

Indexed as

Computer SimulationModels, MolecularMolecular ConformationNucleic AcidsProtein BindingProteinsNucleic AcidsProteins

Identifiers

PMID18281210
PMCPMC2871683
OpenAlexW2082027302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.