ArticleDevelopmental biology2008
Two independent forms of endocytosis maintain embryonic cell surface homeostasis during early development.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Compensatory endocytosis occurs after cortical granule exocytosis in mouse eggs.Journal of cellular physiology · 2020Article
- Cell organelles as targets of mammalian cadmium toxicity.Archives of toxicology · 2020Review
- Application of High-Throughput Assays to Examine Phospho-Modulation of the Late Steps of Regulated Exocytosis.High-throughput · 2017Article
- Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs.Experimental cell research · 2016Article
- Autonomy in specification of primordial germ cells and their passive translocation in the sea urchin.Development (Cambridge, England) · 2012Article
- Programmed reduction of ABC transporter activity in sea urchin germline progenitors.Development (Cambridge, England) · 2012Article
- The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways.PloS one · 2011Article
- Aqueous humor rapidly stimulates myocilin secretion from human trabecular meshwork cells.Experimental eye research · 2010Article
- Membrane wounding triggers ATP release and dysferlin-mediated intercellular calcium signaling.Journal of cell science · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Eukaryotic cells have multiple forms of endocytosis which maintain cell surface homeostasis. One explanation for this apparent redundancy is to allow independent retrieval of surface membranes derived from different types of vesicles. Consistent with this hypothesis we find that sea urchin eggs have at least two types of compensatory endocytosis. One is associated with retrieving cortical vesicle membranes, and formed large endosomes by a mechanism that was inhibited by agatoxin, cadmium, staurosporine and FK506. The second type is thought to compensate for constitutive exocytosis, and formed small endosomes using a mechanism that was insensitive to the above mentioned reagents, but was inhibited by phenylarsine oxide (PAO), and by microinjection of mRNA encoding Src kinase. Both mechanisms could act concurrently, and account for all of the endocytosis occurring during early development. Inhibition of either form did not trigger compensation by the other form, and phorbol ester treatment rescued the endocytotic activity blocked by agatoxin, but not the retrieval blocked by PAO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.