Evidence map›Paper›PMID 18280574›Full record

ReviewPharmacology & therapeutics2008

Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines.

Bhanu P Pappu, Pornpimon Angkasekwinai, Chen Dong

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Dexamethasone reduces IL-17 and Tim-3 expression in BALF of asthmatic mice.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2013
    Article
  6. Article
  7. Article
  8. Review
  9. The role of Interleukin-17A and Interleukin-17E in multiple myeloma patients.Medical science monitor : international medical journal of experimental and clinical research · 2012
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Assessment of the Effects ofAnnals of medical and health sciences research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bhanu P PappuDepartment of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.
Pornpimon Angkasekwinai
Chen Dong
The University of Texas MD Anderson Cancer Center · US

Funding

TSLP Signaling in Dendritic Cells - Aim 3U19AI071130 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ZIEGLER, STEVEN F · 2006 to 2010
$6.1M
Transcriptional regulation of inflammatory helper T Cell differentiationR01AR050772 · NIAMS · UNIVERSITY OF WASHINGTON · PI DONG, CHEN · 2003 to 2016
$4.5M
Signal Transduction and Cytokine Gene Regulation by ICOSR01AI050761 · NIAID · UNIVERSITY OF WASHINGTON · PI DONG, CHEN · 2002 to 2010
$2.3M
Co-stimulatory Regulation of Immune Function &ToleranceR01AI050746 · NIAID · UNIVERSITY OF WASHINGTON · PI DONG, CHEN · 2002 to 2006
$1.5M
NIAID NIH HHS R01 AI050746NIAID NIH HHS R01 AI050761NIAID NIH HHS U19 AI071130NIAMS NIH HHS R01 AR050772
6 · The paper itself

Abstract

Interleukin 17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play critical function in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. Here we summarize recent work by us as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.

Indexed as

AnimalsAsthmaCell DifferentiationHumansInterleukin-17MiceParasitic DiseasesSignal TransductionT-Lymphocytes, Helper-InducerInterleukin-17

Identifiers

PMID18280574
PMCPMC2276145
OpenAlexW2088083775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.