ArticleDevelopmental biology2008
Regulation of the development of tectal neurons and their projections by transcription factors Brn3a and Pax7.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Regeneration-Associated Factors in the Regulation of Adult and Post-Traumatic Neurogenesis in the Forebrain of Fish and Other Vertebrates.International journal of molecular sciences · 2025Review
- Misexpression of ephrin-B2 disrupts laminar patterning in chick optic tectum.Brain structure & function · 2025Article
- Ataxia, intentional tremor and hypotonia syndrome caused by a novelFrontiers in genetics · 2025Article
- Association between humidifier disinfectant exposure during infancy and subsequent neuropsychiatric outcomes during childhood: a nation-wide cross-sectional study.BMC pediatrics · 2021Article
- Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1.Frontiers in neuroanatomy · 2015Article
- Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons.PloS one · 2015Article
- Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.PloS one · 2014Article
- A novel role for FOXA2 and SHH in organizing midbrain signaling centers.Developmental biology · 2012Article
- Space coding by gamma oscillations in the barn owl optic tectum.Journal of neurophysiology · 2011Article
- Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.PLoS genetics · 2009Article
- Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular development.BMC developmental biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The rostral part of the dorsal midbrain, known as the superior colliculus in mammals or the optic tectum in birds, receives a substantial retinal input and plays a diverse and important role in sensorimotor integration. However, little is known about the development of specific subtypes of neurons in the tectum, particularly those which contribute tectofugal projections to the thalamus, isthmic region, and hindbrain. Here we show that two homeodomain transcription factors, Brn3a and Pax7, are expressed in mutually exclusive patterns in the developing and mature avian midbrain. Neurons expressing these factors are generated at characteristic developmental times, and have specific laminar fates within the tectum. In mice expressing betagalactosidase targeted to the Pou4f1 (Brn3a) locus, Brn3a-expressing neurons contribute to the ipsilateral but not the contralateral tectofugal projections to the hindbrain. Using misexpression of Brn3a and Pax7 by electroporation in the chick tectum, combined with GFP reporters, we show that Brn3a determines the laminar fate of subsets of tectal neurons. Furthermore, Brn3a regulates the development of neurons contributing to specific ascending and descending tectofugal pathways, while Pax7 globally represses the development of tectofugal projections to nearly all brain structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.