ArticleDevelopmental biology2008
Expression and function of Dlx genes in the osteoblast lineage.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 92 citations in OpenAlex.
- A Comprehensive Review Exploring the Role of Bone Morphogenetic Proteins [BMP]: Biological Mechanisms.Current issues in molecular biology · 2025Review
- Expression of Dlx-5 and HLX Proteins in Odontogenic Cysts.Life (Basel, Switzerland) · 2025Article
- Article
- Review
- Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases.International journal of molecular sciences · 2022Review
- Genome-scale actions of master regulators directing skeletal development.The Japanese dental science review · 2021Review
- Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Review
- Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells.Molecular medicine reports · 2021Article
- Combined deletions of IHH and NHEJ1 cause chondrodystrophy and embryonic lethality in the Creeper chicken.Communications biology · 2020Article
- The Bone-Forming Properties of Periosteum-Derived Cells Differ Between Harvest Sites.Frontiers in cell and developmental biology · 2020Article
- Transcriptome analysis reveals differentially expressed genes between human primary bone marrow mesenchymal stem cells and human primary dermal fibroblasts.Turkish journal of biology = Turk biyoloji dergisi · 2019Article
- Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts.Molecular medicine reports · 2018Article
- Article
- Article
- Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.Cell death & disease · 2017Article
- Identification of the gene-regulatory landscape in skeletal development and potential links to skeletal regeneration.Regenerative therapy · 2017Review
- Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinctEpigenetics & chromatin · 2017Article
- Article
- Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Our laboratory and others have shown that overexpression of Dlx5 stimulates osteoblast differentiation. Dlx5(-/-)/Dlx6(-/-) mice have more severe craniofacial and limb defects than Dlx5(-/-), some of which are potentially due to defects in osteoblast maturation. We wished to investigate the degree to which other Dlx genes compensate for the lack of Dlx5, thus allowing normal development of the majority of skeletal elements in Dlx5(-/-) mice. Dlx gene expression in cells from different stages of the osteoblast lineage isolated by FACS sorting showed that Dlx2, Dlx5 and Dlx6 are expressed most strongly in less mature osteoblasts, whereas Dlx3 is very highly expressed in differentiated osteoblasts and osteocytes. In situ hybridization and Northern blot analysis demonstrated the presence of endogenous Dlx3 mRNA within osteoblasts and osteocytes. Dlx3 strongly upregulates osteoblastic markers with a potency comparable to Dlx5. Cloned chick or mouse Dlx6 showed stimulatory effects on osteoblast differentiation. Our results suggest that Dlx2 and Dlx6 have the potential to stimulate osteoblastic differentiation and may compensate for the absence of Dlx5 to produce relatively normal osteoblastic differentiation in Dlx5 knockout mice, while Dlx3 may play a distinct role in late stage osteoblast differentiation and osteocyte function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.