ArticleGene2008
Molecular and functional characterization of a tandem-repeat galectin from the freshwater snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni.
Article in Gene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
- Computer-aided molecular and biological-immune modeling of illicium verum bioactive compounds employing the Egyptian Nile snail Biomphalaria alexandrina as a paradigm.Journal of computer-aided molecular design · 2025Article
- A NovelInternational journal of molecular sciences · 2024Article
- Harnessing the power of mollusc lectins as immuno-protective biomolecules.Molecular biology reports · 2024Review
- Galectin from Trichinella spiralis alleviates DSS-induced colitis in mice by regulating the intestinal microbiota.Veterinary research · 2024Article
- Fluorescent non transgenic schistosoma to decipher host-parasite phenotype compatibility.Frontiers in immunology · 2023Article
- Mollusc N-glycosylation: Structures, Functions and Perspectives.Biomolecules · 2021Review
- Efficacy of Miltefosine and Artemether on InfectedHelminthologia · 2020Article
- Biomphalaria glabrata immunity: Post-genome advances.Developmental and comparative immunology · 2020Review
- Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins.Frontiers in immunology · 2019Review
- Molecular characterization of Trichinella spiralis galectin and its participation in larval invasion of host's intestinal epithelial cells.Veterinary research · 2018Article
- The roles of galectins in parasitic infections.Acta tropica · 2018Review
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- A novel and stress adaptive alternative oxidase derived from alternative splicing of duplicated exon in oyster Crassostrea virginica.Scientific reports · 2017Article
- Differential Protein Expression in the Hemolymph of Bithynia siamensis goniomphalos Infected with Opisthorchis viverrini.PLoS neglected tropical diseases · 2016Article
- Identification of a Novel Nematotoxic Protein by Challenging the Model Mushroom Coprinopsis cinerea with a Fungivorous Nematode.G3 (Bethesda, Md.) · 2015Article
- Structural, functional, and evolutionary aspects of galectins in aquatic mollusks: From a sweet tooth to the Trojan horse.Fish & shellfish immunology · 2015Review
- Digenean-gastropod host associations inform on aspects of specific immunity in snails.Developmental and comparative immunology · 2015Review
- Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini.Journal of proteomics · 2015Article
- A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata.Developmental and comparative immunology · 2015Article
- RNA-Seq reveals infection-induced gene expression changes in the snail intermediate host of the carcinogenic liver fluke, Opisthorchis viverrini.PLoS neglected tropical diseases · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In the present study, a tandem-repeat type galectin was characterized from an embryonic cell line (Bge) and circulating hemocytes of the snail Biomphalaria glabrata, intermediate host of the human blood fluke Schistosoma mansoni. The predicted B. glabrata galectin (BgGal) protein of 32 kDa possessed 2 carbohydrate recognition domains, each displaying 6 of 8 conserved amino acids involved in galactoside-binding activity. A recombinant BgGal (rBgGal) demonstrated hemagglutinating activity against rabbit erythrocytes, which was specifically inhibited by galactose-containing sugars (lacNAc/lac>galNAc/gal). Although native galectin was immunolocalized in the cytoplasm of Bge cells and the plasma membrane of a subset of snail hemocytes (60%), it was not detected in cell-free plasma by Western blot analysis. The findings that rBgGal selectively recognizes the schistosome-related sugar, lacNAc, and strongly binds to hemocytes and the tegument of S. mansoni sporocysts in a sugar-inhibitable fashion suggest that hemocyte-bound galectin may be serving as a pattern recognition receptor for this, or other pathogens possessing appropriate sugar ligands. Based on molecular and functional features, BgGal represents an authentic galectin, the first to be fully characterized in the medically-important molluscan Class Gastropoda.
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