ArticleJournal of theoretical biology2008
Stochastic simulation of actin dynamics reveals the role of annealing and fragmentation.
Article in Journal of theoretical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Emergence and maintenance of variable-length actin filaments in a limiting pool of building blocks.Biophysical journal · 2022Article
- Quantitative computational models of molecular self-assembly in systems biology.Physical biology · 2017Review
- Efficient Multiscale Models of Polymer Assembly.Biophysical journal · 2016Article
- MEDYAN: Mechanochemical Simulations of Contraction and Polarity Alignment in Actomyosin Networks.PLoS computational biology · 2016Article
- How Cells Measure Length on Subcellular Scales.Trends in cell biology · 2015Review
- Combinative in vitro studies and computational model to predict 3D cell migration response to drug insult.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Quantitative analysis of approaches to measure cooperative phosphate release in polymerized actin.Biophysical journal · 2012Article
- A theoretical analysis of filament length fluctuations in actin and other polymers.Journal of mathematical biology · 2011Article
- Fragmentation is crucial for the steady-state dynamics of actin filaments.Biophysical journal · 2011Article
- Mechanisms controlling cell size and shape during isotropic cell spreading.Biophysical journal · 2010Article
- Role of ATP-hydrolysis in the dynamics of a single actin filament.Biophysical journal · 2010Article
- A mathematical model of actin filament turnover for fitting FRAP data.European biophysics journal : EBJ · 2010Article
- Growing actin networks form lamellipodium and lamellum by self-assembly.Biophysical journal · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recent observations of F-actin dynamics call for theoretical models to interpret and understand the quantitative data. A number of existing models rely on simplifications and do not take into account F-actin fragmentation and annealing. We use Gillespie's algorithm for stochastic simulations of the F-actin dynamics including fragmentation and annealing. The simulations vividly illustrate that fragmentation and annealing have little influence on the shape of the polymerization curve and on nucleotide profiles within filaments but drastically affect the F-actin length distribution, making it exponential. We find that recent surprising measurements of high length diffusivity at the critical concentration cannot be explained by fragmentation and annealing events unless both fragmentation rates and frequency of undetected fragmentation and annealing events are greater than previously thought. The simulations compare well with experimentally measured actin polymerization data and lend additional support to a number of existing theoretical models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.