Evidence map›Paper›PMID 18279816›Full record

Trial reportTranslational research : the journal of laboratory and clinical medicine2008

Selective serotonin reuptake inhibitors: measurement of effect on platelet function.

Donna Jo McCloskey, Teodor T Postolache, Bernard J Vittone, Khanh L Nghiem, Jude L Monsale, Robert A Wesley, Margaret E Rick

Abstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational research : the journal of laboratory and clinical medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  5. Observational
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  18. Pharmacologic Treatment and Management of Coronavirus Disease 2019.Infectious disease clinics of North America · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Donna Jo McCloskeyNational Institutes of Health, Warren Grant Magnuson Clinical Center, Department of Laboratory Medicine, Bethesda, MD 20892, USA. mccloskd@mail.nih.gov
Teodor T Postolache
Bernard J Vittone
Khanh L Nghiem
Jude L Monsale
Robert A Wesley
Margaret E Rick
National Institutes of Health · USUniversity of Maryland, Baltimore · US

Funding

Intramural NIH HHS Z99 RR999999
6 · The paper itself

Abstract

Selective serotonin reuptake inhibitors (SSRIs) reduce platelet serotonin and are associated with increased gastrointestinal bleeding, an effect that is enhanced when taken with NSAIDs or aspirin. The best method to evaluate hemorrhagic events in patients taking SSRIs has not been determined. Platelet aggregation, which is not widely available, shows SSRI inhibition of platelet function; we tested whether a platelet function analyzer could detect SSRI inhibition of platelet function. Two groups of outpatients with mood disorders were recruited; each patient was taking a stable dose of either an SSRI or bupropion for at least 6 weeks. They were tested using the platelet function analyzer-100 (PFA-100; Dade International Inc, Miami, Fla) concomitantly with platelet aggregation. Fifty-eight patients were analyzed. We detected significant differences between the groups using aggregation methods with arachidonic acid (aggregation, P = 0.00001; release, P = 0.009) and collagen (aggregation, P = 0.016; release, P = 0.006). The PFA-100 did not detect differences between the groups or results outside the reference range. The PFA-100 does not detect the inhibitory effects of SSRIs on platelet function, but it can be used to direct evaluation of bleeding in a patient taking an SSRI. Abnormal PFA-100 results suggest additional evaluation for von Willebrand disease, other platelet inhibitory medications, or underlying intrinsic platelet dysfunction.

Indexed as

AdultAgedBlood PlateletsBupropionCollagenEpinephrineFemaleHumansMaleMiddle AgedPlatelet AggregationSelective Serotonin Reuptake InhibitorsThrombinBupropionCollagenEpinephrineSelective Serotonin Reuptake InhibitorsThrombin

Identifiers

PMID18279816
PMCPMC2391274
OpenAlexW2097638389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.