ArticleBMC plant biology2008
Global gene expression analysis of apple fruit development from the floral bud to ripe fruit.
Article in BMC plant biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 236 citations in OpenAlex.
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- Microbial community succession and dynamics during the season-long development of apple fruit (Microbiology spectrum · 2026Article
- Growth regulation during early fruit development in apple (Malus × domestica Borkh.): a temporal event map of transcriptome and phytohormone changes.BMC plant biology · 2025Article
- Integrative transcriptomics and phenotyping uncover genetic networks controlling fruit quality in two strawberries (Frontiers in plant science · 2025Article
- An InDel variant in the promoter of the NAC transcription factor MdNAC18.1 plays a major role in apple fruit ripening.The Plant cell · 2024Article
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- Estimating Transcriptome Diversity and Specialization inPlants (Basel, Switzerland) · 2024Article
- Genetic variations inMolecular breeding : new strategies in plant improvement · 2024Article
- Molecular regulation of apple and grape ripening: exploring common and distinct transcriptional aspects of representative climacteric and non-climacteric fruits.Journal of experimental botany · 2023Review
- A molecular phenology scale of grape berry development.Horticulture research · 2023Article
- Fruit growth and development in apple: a molecular, genomics and epigenetics perspective.Frontiers in plant science · 2023Review
- RSNET: inferring gene regulatory networks by a redundancy silencing and network enhancement technique.BMC bioinformatics · 2022Article
- Role of Melatonin in Apple Fruit during Growth and Ripening: Possible Interaction with Ethylene.Plants (Basel, Switzerland) · 2022Article
- Extreme sugar accumulation in late fig ripening is accompanied by global changes in sugar metabolism and transporter gene expression.Physiologia plantarum · 2022Article
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- Characterization of the genetic and regulatory networks associated with sugar and acid metabolism in applesFrontiers in plant science · 2022Article
- Early Sucrose Degradation and the Dominant Sucrose Cleavage Pattern InfluenceInternational journal of molecular sciences · 2021Article
- The role of auxin during early berry development in grapevine as revealed by transcript profiling from pollination to fruit set.Horticulture research · 2021Article
- In Response to Abiotic Stress, DNA Methylation Confers EpiGenetic Changes in Plants.Plants (Basel, Switzerland) · 2021Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApple fruit develop over a period of 150 days from anthesis to fully ripe. An array representing approximately 13000 genes (15726 oligonucleotides of 45-55 bases) designed from apple ESTs has been used to study gene expression over eight time points during fruit development. This analysis of gene expression lays the groundwork for a molecular understanding of fruit growth and development in apple.
resultsUsing ANOVA analysis of the microarray data, 1955 genes showed significant changes in expression over this time course. Expression of genes is coordinated with four major patterns of expression observed: high in floral buds; high during cell division; high when starch levels and cell expansion rates peak; and high during ripening. Functional analysis associated cell cycle genes with early fruit development and three core cell cycle genes are significantly up-regulated in the early stages of fruit development. Starch metabolic genes were associated with changes in starch levels during fruit development. Comparison with microarrays of ethylene-treated apple fruit identified a group of ethylene induced genes also induced in normal fruit ripening. Comparison with fruit development microarrays in tomato has been used to identify 16 genes for which expression patterns are similar in apple and tomato and these genes may play fundamental roles in fruit development. The early phase of cell division and tissue specification that occurs in the first 35 days after pollination has been associated with up-regulation of a cluster of genes that includes core cell cycle genes.
conclusionGene expression in apple fruit is coordinated with specific developmental stages. The array results are reproducible and comparisons with experiments in other species has been used to identify genes that may play a fundamental role in fruit development.
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