ArticleGenome biology2008
Functional protein divergence in the evolution of Homo sapiens.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Biomedical literature mining: graph kernel-based learning for gene-gene interaction extraction.European journal of medical research · 2024Article
- Transcription factor roles in the local adaptation to temperature in the Andean Spiny Toad Rhinella spinulosa.Scientific reports · 2024Article
- Evolution of tissue-specific expression of ancestral genes across vertebrates and insects.Nature ecology & evolution · 2024Article
- FuncPEP v2.0: An Updated Database of Functional Short Peptides Translated from Non-Coding RNAs.Non-coding RNA · 2024Article
- Predicting gene expression divergence between single-copy orthologs in two species.Genome biology and evolution · 2023Article
- Three Tiers to biological escape velocity: The quest to outwit aging.Aging medicine (Milton (N.S.W)) · 2022Review
- Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins.Frontiers in molecular biosciences · 2021Article
- FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs.Non-coding RNA · 2020Article
- Dynamics of genetic variation in transcription factors and its implications for the evolution of regulatory networks in Bacteria.Nucleic acids research · 2020Article
- Hypothesis: protein and RNA attributes are continuously optimized over time.BMC genomics · 2019Article
- A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.Nature communications · 2018Article
- Modelling the evolution of transcription factor binding preferences in complex eukaryotes.Scientific reports · 2017Article
- Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function.BMC bioinformatics · 2016Article
- SinEx DB: a database for single exon coding sequences in mammalian genomes.Database : the journal of biological databases and curation · 2016Article
- Sample Level Enrichment Analysis of KEGG Pathways Identifies Clinically Relevant Subtypes of Glioblastoma.Journal of Cancer · 2016Article
- Dry and wet approaches for genome-wide functional annotation of conventional and unconventional transcriptional activators.Computational and structural biotechnology journal · 2016Review
- Elucidating the genotype-phenotype relationships and network perturbations of human shared and specific disease genes from an evolutionary perspective.Genome biology and evolution · 2014Article
- Hierarchical partitioning of metazoan protein conservation profiles provides new functional insights.PloS one · 2014Article
- Effect of duplicate genes on mouse genetic robustness: an update.BioMed research international · 2014Article
- Expression of polycomb targets predicts breast cancer prognosis.Molecular and cellular biology · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundProtein-coding regions in a genome evolve by sequence divergence and gene gain and loss, altering the gene content of the organism. However, it is not well understood how this has given rise to the enormous diversity of metazoa present today.
resultsTo obtain a global view of human genomic evolution, we quantify the divergence of proteins by functional category at different evolutionary distances from human.
conclusionThis analysis highlights some general systems-level characteristics of human evolution: regulatory processes, such as signal transducers, transcription factors and receptors, have a high degree of plasticity, while core processes, such as metabolism, transport and protein synthesis, are largely conserved. Additionally, this study reveals a dynamic picture of selective forces at short, medium and long evolutionary timescales. Certain functional categories, such as 'development' and 'organogenesis', exhibit temporal patterns of sequence divergence in eukaryotes relative to human. This framework for a grammar of human evolution supports previously postulated theories of robustness and evolvability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.