Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

56 citing papers in PubMed.

1. Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells.iScience · 2026
   Article
2. Blood measure of neuronal death is exponentially higher with age, especially in females, and halted in Alzheimer's disease by GM-CSF treatment.Cell reports. Medicine · 2026
   Article
3. Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress.Journal of molecular neuroscience : MN · 2024
   Article
4. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease.Research square · 2024
   Article
5. Somatic copy number variant load in neurons of healthy controls and Alzheimer's disease patients.Acta neuropathologica communications · 2022
   Article
6. Reducing the aneuploid cell burden - cell competition and the ribosome connection.Disease models & mechanisms · 2022
   Review
7. p27, The Cell Cycle and Alzheimer´s Disease.International journal of molecular sciences · 2022
   Review
8. Brain Somatic Mutation in Aging and Alzheimer's Disease.Annual review of genomics and human genetics · 2021
   Review
9. Further understanding the connection between Alzheimer's disease and Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020
   Review
10. "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.Aging cell · 2020
    Review
11. Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer's Disease.Frontiers in genetics · 2020
    Article
12. Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA - Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimer's Disease?Frontiers in genetics · 2020
    Review
13. Somatic mosaicism of sex chromosomes in the blood and brain.Brain research · 2019
    Article
14. Seizure in Alzheimer's Disease: An Underestimated Phenomenon.American journal of Alzheimer's disease and other dementias · 2019
    Review
15. Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders.Frontiers in genetics · 2019
    Article
16. Genomic mosaicism in the developing and adult brain.Developmental neurobiology · 2018
    Review
17. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model.Aging cell · 2018
    Article
18. Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations.Molecular biology of the cell · 2018
    Article
19. Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Article
20. Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain.Mechanisms of ageing and development · 2017
    Review

Corrections and comments

• Commented on by
  Maternal age, somatic mosaicism, and Alzheimer disease.1992

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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