Evidence map›Paper›PMID 18278988›Full record

Trial reportThe Journal of clinical psychiatry2008

The efficacy of acute electroconvulsive therapy in atypical depression.

Mustafa M Husain, Shawn M McClintock, A John Rush, Rebecca G Knapp, Max Fink, Teresa A Rummans, Keith Rasmussen, Cynthia Claassen, Georgios Petrides, Melanie M Biggs and 5 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000375 (Continuation ECT Vs Pharmacotherapy--Efficacy And Safety), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000375 phase4completednot on this map

Continuation ECT Vs Pharmacotherapy--Efficacy And Safety

TypeinterventionalSponsorNational Institute of Mental Health (NIMH)Ran1997ConditionsMajor Depressive DisorderArmsNortriptyline-lithium (NOR-Li), Bilateral electroconvulsive therapy (ECT), Continuation therapy, Continuation ECT
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
  5. Review
  6. Atypical depression: current perspectives.Neuropsychiatric disease and treatment · 2017
    Review
  7. Neuromodulation for treatment-refractory major depressive disorder.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Mustafa M HusainDepartment of Psychiatry, University of Texas (UT) Southwestern Medical Center at Dallas, TX 75390-8898, USA. mustafa.husain@utsouthwestern.edu
Shawn M McClintock
A John Rush
Rebecca G Knapp
Max Fink
Teresa A Rummans
Keith Rasmussen
Cynthia Claassen
Georgios Petrides
Melanie M Biggs
Martina Mueller
Shirlene Sampson
Samuel H Bailine
Sarah H Lisanby
Charles H Kellner
Mayo Clinic · USMedical University of South Carolina · USRutgers, The State University of New Jersey · USThe University of Texas Southwestern Medical Center · USZucker Hillside Hospital · USColumbia University · USSouthwestern Medical Center · US

Funding

1/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH055495 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLNER, CHARLES H · 2009 to 2013
$2.0M
Continuation ECT vs Pharmacotherapy: Efficacy and SafetyR01MH055495 · NIMH · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KELLNER, CHARLES H · 2002 to 2003
$819k
CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETYR10MH055495 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KELLNER, CHARLES H · 1997 to 2001
$709k
CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETYR01MH055486 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI PETRIDES, GEORGIOS · 2002 to 2003
$661k
Continuation ECT versus PharmacotherapyR01MH055489 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI HUSAIN, MUSTAFA M. · 2002 to 2003
$651k
CONTINUATION ECT VS PHARMACOTHERAPHY--SAFETY &EFFICACYR10MH055489 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI HUSAIN, MUSTAFA M. · 1997 to 2001
$636k
Continuation ECT vs Pharmacotherapy: Efficacy &SafetyR01MH055484 · NIMH · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI RUMMANS, TERESA A · 2002 to 2003
$553k
CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETYR10MH055486 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI PETRIDES, GEORGIOS · 1997 to 2001
$548k
CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETYR10MH055484 · NIMH · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI RUMMANS, TERESA A · 1997 to 2001
$540k
NIMH NIH HHS MH55484NIMH NIH HHS MH55485NIMH NIH HHS MH55486NIMH NIH HHS MH55489NIMH NIH HHS MH55495NIMH NIH HHS R01 MH055484NIMH NIH HHS R01 MH055486NIMH NIH HHS R01 MH055489NIMH NIH HHS R01 MH055495NIMH NIH HHS R10 MH055484NIMH NIH HHS R10 MH055486NIMH NIH HHS R10 MH055489NIMH NIH HHS R10 MH055495NIMH NIH HHS U01 MH055495
6 · The paper itself

Abstract

objectiveThis study examined the characteristics and outcomes of patients with major depressive disorder (MDD), with or without atypical features, who were treated with acute bilateral electroconvulsive therapy (ECT).

methodAnalyses were conducted with 489 patients who met DSM-IV criteria for MDD. Subjects were identified as typical or atypical on the basis of the Structured Clinical Interview for DSM-IV obtained at baseline prior to ECT. Depression symptom severity was measured by the 24-item Hamilton Rating Scale for Depression (HAM-D(24)) and the 30-item Inventory of Depressive Symptomatology-Self-Report (IDS-SR(30)). Remission was defined as at least a 60% decrease from baseline in HAM-D(24) score and a total score of 10 or below on the last 2 consecutive HAM-D(24) ratings. The randomized controlled trial was performed from 1997 to 2004.

resultsThe typical (N = 453) and atypical (N = 36) groups differed in several sociodemographic and clinical variables including gender (p = .0071), age (p = .0005), treatment resistance (p = .0014), and age at first illness onset (p < .0001) and onset of current episode (p = .0008). Following an acute course of bilateral ECT, a considerable portion of both the typical (67.1%) and the atypical (80.6%) groups reached remission. The atypical group was 2.6 (95% CI = 1.1 to 6.2) times more likely to remit than the typical group after adjustment for age, psychosis, gender, clinical site, and depression severity based on the HAM-D(24).

conclusionAcute ECT is an efficacious treatment for depressed patients with typical or atypical symptom features.

trial registrationclinicaltrials.gov Identifier: NCT00000375.

Indexed as

AdolescentAdultAgedAged, 80 and overCatchment Area, HealthElectroconvulsive TherapyFemaleHumansMajor Depressive DisorderMaleMiddle AgedObserver VariationPsychiatric Status Rating ScalesTime FactorsTreatment Outcome

Identifiers

PMID18278988
PMCPMC3670137
OpenAlexW2083564374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.