ArticleLangmuir : the ACS journal of surfaces and colloids2008
Reduced blinking and long-lasting fluorescence of single fluorophores coupling to silver nanoparticles.
Article in Langmuir : the ACS journal of surfaces and colloids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Localization Study of Photostable Alexa 488 at Single Molecule Level.Journal of fluorescence · 2025Article
- A New Fluorescent Probe for Hydrogen Sulfide Detection in Solution and Living Cells.Molecules (Basel, Switzerland) · 2023Article
- Modulation and study of photoblinking behavior in dye doped silver-silica core-shell nanoparticles for localization super-resolution microscopy.Nanotechnology · 2019Article
- Fluorescence Spectroscopy with Metal-Dielectric Waveguides.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
- Fluorescence Intensity and Lifetime Cell Imaging with Luminescent Gold Nanoclusters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2012Article
- Silver-Gold Nanocomposite Substrates for Metal-Enhanced Fluorescence: Ensemble and Single-Molecule Spectroscopic Studies.The journal of physical chemistry. C, Nanomaterials and interfaces · 2012Article
- Nanoscaled ZnO films used as enhanced substrates for fluorescence detection of dyes.Chinese physics B = Zhongguo wu li B · 2012Article
- Photophysical behaviors of single fluorophores localized on zinc oxide nanostructures.International journal of molecular sciences · 2012Article
- Prism-based spectral imaging of single-molecule fluorescence from gold-nanoparticle/fluorophore complex.Journal of fluorescence · 2011Article
- Metallic-Nanostructure-Enhanced Fluorescence of Single Flavin Cofactor and Single Flavoenzyme Molecules.The journal of physical chemistry. C, Nanomaterials and interfaces · 2011Article
- Fluorescent avidin-bound silver particle: a strategy for single target molecule detection on a cell membrane.Analytical chemistry · 2009Article
- Silver-enhanced fluorescence emission of single quantum dot nanocomposites.Chemical communications (Cambridge, England) · 2009Article
- Metal-enhanced fluorescence of single green fluorescent protein (GFP).Biochemical and biophysical research communications · 2008Article
- Enhanced fluorescence images for labeled cells on silver island films.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Plasmon-Coupled Fluorescence Probes: Effect of Emission Wavelength on Fluorophore-Labeled Silver Particles.The journal of physical chemistry. C, Nanomaterials and interfaces · 2008Article
- Single molecule photophysics near metallic nanostructures.Proceedings of SPIE--the International Society for Optical Engineering · 2008Article
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3 authors.
Funding
Abstract
The fluorescence signal of single organic fluorophores is characterized by random blinking and irreversible photobleaching. Photoinduced blinking of Cy5 has posed various limitations of this popular near-infrared (NIR) probe in biological applications. Here we show that fluorophore-metal nanoparticle (NP) complexes greatly suppress Cy5 blinking and noticeably reduce photobleaching events. The blinking behavior of single Cy5 molecules was investigated and compared in the absence and the presence of silver nanostructures. A power-law distribution of off time population was observed for single Cy5 molecules. Average off times were compared to evaluate the plasmonic effect of silver nanoparticles on the triplet decay rates. We furthermore demonstrate enhanced photostability in the presence of silver NPs. The results show that plasmonic-controlled fluorescence can lead to a novel physical mechanism to enhance fluorescence intensity, reduce blinking, and increase photostability.
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