Evidence map›Paper›PMID 18278223›Full record

ArticleBrazilian journal of otorhinolaryngology

Expression of basement membrane laminin in oral squamous cell carcinomas.

Silvia Regina de Almeida Reis, Leonardo Francisco Provedel de Souza, Verônica Ferreira de Souza, Lílian Dantas de Góes Silva, Jean Nunes Dos Santos

Open access · goldAbstract read
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Expression of Laminin in Oral Squamous Cell CarcinomasAsian Pacific journal of cancer prevention : APJCP · 2018
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Silvia Regina de Almeida ReisDoctorate in Dentistry, Adjunct Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University. Electronic address: srareis@uol.com.br.
Leonardo Francisco Provedel de SouzaMaster's degree in Dentistry, Substitute Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University.
Verônica Ferreira de SouzaMaster's degree in Dentistry, Assistant Professor, Dentistry School of the Southwestern Bahia State University.
Lílian Dantas de Góes SilvaBolsista do Programa de Educação Tutorial, Graduanda da Faculdade de Odontologia da Universidade Federal da Bahia.
Jean Nunes Dos SantosDoctorate in Dentistry, Adjunct Professor of the Integrated Clinic and Propedeutics Department, Dentistry School of the Bahia Federal University.
Universidade Federal da Bahia · BRUniversidade do Estado da Bahia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe basement membrane is a dynamic structure that undergoes quantitative and qualitative changes during the progression of squamous cell carcinoma, which is essentially important in tumoral invasion and metastasis.

aimThis study is aimed at investigating the behavior of the basement membrane in oral squamous cell carcinomas with different malignancy scores, which were obtained through the immunohistochemical expression of the laminin, a glycoprotein present in the basement membrane. STUDY

designHistory cross-sectional cohort. MATERIAL AND

methodThirty-one cases of oral squamous cell carcinoma were subjected to histological grading of malignant tumors. The immunohistochemical expression of the laminin in lesions bearing different scores of malignancy was evaluated according to intensity and integrity, using the Streptavidin-Biotin complex method.

resultsWe noticed significant differences in the media between intensity and continuity laminin expression in relation to different grades of malignancy.

conclusionDifferent expressions of laminin, a glycoprotein present in basement membranes were evident in oral cell carcinomas within different grades of histological malignancy.

Indexed as

AdultAgedAged, 80 and overBasement MembraneBiomarkers, TumorCarcinoma, Squamous CellCohort StudiesCross-Sectional StudiesFemaleHumansImmunohistochemistryLamininMaleMiddle AgedMouth NeoplasmsNeoplasm StagingBiomarkers, TumorLaminin

Identifiers

PMID18278223
PMCPMC9450599
OpenAlexW2703249031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.