Trial reportThe Pediatric infectious disease journal2008
Risk factors for late postnatal transmission of human immunodeficiency virus type 1 in sub-Saharan Africa.
Trial report in The Pediatric infectious disease journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- An optimized strategy triggered at the 2nd immunization visit to prevent HIV acquisition by breastfeeding: a phase 2 trial in Burkina Faso (PREVENIR-PEV).BMC infectious diseases · 2024Trial
- Determining an optimal testing strategy for infants at risk for mother-to-child transmission of HIV-1 during the late postnatal period.AIDS (London, England) · 2008Trial
- Frequency of Viremic Episodes in HIV-Infected Women Initiating Antiretroviral Therapy During Pregnancy: A Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Recent Insights into the HIV/AIDS Pandemic.Microbial cell (Graz, Austria) · 2016Review
- Maternal risk factors for HIV infection in infants in northeastern Brazil.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2013Article
- Development of a measure of the patient-provider relationship in antenatal care and its importance in PMTCT.AIDS care · 2012Article
- Population attributable fractions for late postnatal mother-to-child transmission of HIV-1 in Sub-Saharan Africa.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Primary HIV-1 infection among infants in sub-Saharan Africa: HPTN 024.Journal of acquired immune deficiency syndromes (1999) · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundWe conducted secondary data analyses of a clinical trial (HIVNET 024) to assess risk factors for late postnatal transmission (LPT) of human immunodeficiency virus type 1 (HIV-1) through breast-feeding.
methodsData regarding live born, singleton infants of HIV-1-infected mothers were analyzed. The timing of HIV-1 transmission through 12 months after birth was defined as: in utero (positive HIV-1 RNA results at birth), perinatal/early postnatal (negative results at birth, positive at 4-6 week visit), or LPT (negative results through the 4-6 week visit, but positive assays thereafter through the 12-month visit). HIV-1-uninfected infants were those with negative HIV-1 enzyme immunoassay results at 12 months of age, or infants with negative HIV-1 RNA results throughout follow-up.
resultsOf 2292 HIV-1-infected enrolled women, 2052 mother/infant pairs met inclusion criteria. Of 1979 infants with HIV-1 tests, 404 were HIV-1-infected, and 382 had known timing of infection (LPT represented 22% of transmissions). Further analyses of LPT included infants who were breast-feeding at the 4-6 week visit (with negative HIV-1 results at that visit) revealed 6.9% of 1317 infants acquired HIV-1 infection through LPT by 12 months of age. More advanced maternal HIV-1 disease at enrollment (lower CD4 counts, higher plasma viral loads) were the factors associated with LPT in adjusted analyses.
conclusionsIn this breast-feeding population, 6.9% of infants uninfected at 6 weeks of age acquired HIV-1 infection by 12 months. Making interventions to decrease the risk of LPT of HIV-1 available and continuing research regarding the mechanisms of LPT (so as to develop improved interventions to reduce such transmission) remain essential.
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