ArticleMolecular systems biology2008
Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression.
Article in Molecular systems biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.Developmental biology · 2022Article
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
- Game of Tissues: How the Epidermis ThronesJournal of developmental biology · 2020Review
- Combinatorial decoding of the invariant C. elegans embryonic lineage in space and time.Genesis (New York, N.Y. : 2000) · 2016Review
- Digital development: a database of cell lineage differentiation in C. elegans with lineage phenotypes, cell-specific gene functions and a multiscale model.Nucleic acids research · 2016Article
- Collaborative regulation of development but independent control of metabolism by two epidermis-specific transcription factors in Caenorhabditis elegans.The Journal of biological chemistry · 2013Article
- Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification.Development (Cambridge, England) · 2013Article
- The Influence of Competition AmongGenes · 2012Article
- Transcription factor redundancy and tissue-specific regulation: evidence from functional and physical network connectivity.Genome research · 2012Article
- A regulatory network modeled from wild-type gene expression data guides functional predictions in Caenorhabditis elegans development.BMC systems biology · 2012Article
- Functional inference of complex anatomical tendinous networks at a macroscopic scale via sparse experimentation.PLoS computational biology · 2012Article
- Regulation of sperm gene expression by the GATA factor ELT-1.Developmental biology · 2009Article
- Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network.Development (Cambridge, England) · 2009Article
- Identification of an inter-transcription factor regulatory network in human hepatoma cells by Matrix RNAi.Nucleic acids research · 2009Article
- Gene module level analysis: identification to networks and dynamics.Current opinion in biotechnology · 2008Review
- The Caenorhabditis elegans epidermis as a model skin. I: development, patterning, and growth.Wiley interdisciplinary reviews. Developmental biologyReview
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9 authors.
Funding
Abstract
Biological networks are inherently modular, yet little is known about how modules are assembled to enable coordinated and complex functions. We used RNAi and time series, whole-genome microarray analyses to systematically perturb and characterize components of a Caenorhabditis elegans lineage-specific transcriptional regulatory network. These data are supported by selected reporter gene analyses and comprehensive yeast one-hybrid and promoter sequence analyses. Based on these results, we define and characterize two modules composed of muscle- and epidermal-specifying transcription factors that function together within a single cell lineage to robustly specify multiple cell types. The expression of these two modules, although positively regulated by a common factor, is reliably segregated among daughter cells. Our analyses indicate that these modules repress each other, and we propose that this cross-inhibition coupled with their relative time of induction function to enhance the initial asymmetry in their expression patterns, thus leading to the observed invariant gene expression patterns and cell lineage. The coupling of asynchronous and topologically distinct modules may be a general principle of module assembly that functions to potentiate genetic switches.
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