ArticleAmerican journal of respiratory cell and molecular biology2008
SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase.
Article in American journal of respiratory cell and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation.Toxicological research · 2023Article
- Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation.Archives of biochemistry and biophysics · 2017Review
- Redox signaling: An evolution from free radicals to aging.Free radical biology & medicine · 2016Review
- Redox homeostasis: The Golden Mean of healthy living.Redox biology · 2016Article
- 4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B.Free radical biology & medicine · 2015Article
- Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product.Toxicology and applied pharmacology · 2014Article
- Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.Oxidative medicine and cellular longevity · 2014Review
- Antioxidant therapeutics: Pandora's box.Free radical biology & medicine · 2014Review
- Farnesoid X receptor ligand prevents cisplatin-induced kidney injury by enhancing small heterodimer partner.PloS one · 2014Article
- Glutathione synthesis and its role in redox signaling.Seminars in cell & developmental biology · 2012Review
- The effects of chromium(VI) on the thioredoxin system: implications for redox regulation.Free radical biology & medicine · 2012Review
- The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling.Molecular nutrition & food research · 2011Review
- SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy.American journal of obstetrics and gynecology · 2011Article
- Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.Clinical and experimental gastroenterology · 2011Article
- C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements.IUBMB life · 2010Article
- Signaling functions of reactive oxygen species.Biochemistry · 2010Review
- Disruption of the mGsta4 gene increases life span of C57BL mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- Article
- The role of c-Jun phosphorylation in EpRE activation of phase II genes.Free radical biology & medicine · 2009Article
- Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.American journal of respiratory cell and molecular biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
4-Hydroxy-2-nonenal (HNE), a major lipid peroxidation product, is toxic at high concentrations, but at near-physiological concentrations it induces detoxifying enzymes. Previous data established that in human bronchial epithelial (HBE1) cells, both genes for glutamate cysteine ligase (GCL) are induced by HNE through the c-Jun N-terminal kinase (JNK) pathway. The protein-tyrosine phosphatase SH2 domain containing phosphatase-1 (SHP-1) is thought to play a role as a negative regulator of cell signaling, and has been implicated as such in the JNK pathway. In the present study, SHP-1 was demonstrated to contribute to HNE-induced-gclc expression via regulation of the JNK pathway in HBE1 cells. Treatment of HBE1 cells with HNE induced phosphorylation of mitogen-activated protein kinase kinase 4 (MKK4), JNK, and c-Jun. HNE was able to inhibit protein tyrosine phosphatase activity of SHP-1 through increased degradation of the protein. Furthermore, transfection with small interference RNA SHP-1 showed an enhancement of JNK and c-Jun phosphorylation, but not of MKK4, leading to increased gclc expression. These results demonstrate that SHP-1 plays a role as a negative regulator of the JNK pathway and that HNE activated the JNK pathway by inhibiting SHP-1. Thus, SHP-1 acts as a sensor for HNE and is responsible for an important adaptive response to oxidative stress.
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