ArticleThe American journal of pathology2008
Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Long-term effects of daily hemodialysis on vascular access outcomes: a prospective controlled study.Hemodialysis international. International Symposium on Home Hemodialysis · 2013Trial
- Inflammation in Vein Graft Disease.Frontiers in cardiovascular medicine · 2018Review
- Vein graft failure: from pathophysiology to clinical outcomes.Nature reviews. Cardiology · 2016Review
- Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima.Kidney international · 2015Article
- Arterial grafts exhibiting unprecedented cellular infiltration and remodeling in vivo: the role of cells in the vascular wall.Biomaterials · 2015Article
- Biological effects of anti-CD34-coated ePTFE vascular grafts. Early in vivo experimental results.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2014Article
- Vein graft adaptation and fistula maturation in the arterial environment.The Journal of surgical research · 2014Review
- Novel paradigms for dialysis vascular access: downstream vascular biology--is there a final common pathway?Clinical journal of the American Society of Nephrology : CJASN · 2013Review
- Characteristics of the actions by which 5-hydroxytryptamine affects electrical and mechanical activities in rabbit jugular vein graft.British journal of pharmacology · 2012Article
- Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.Blood · 2012Article
- Mouse vein graft hemodynamic manipulations to enhance experimental utility.The American journal of pathology · 2011Article
- Decellularized tissue-engineered blood vessel as an arterial conduit.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Rationale and practical techniques for mouse models of early vein graft adaptations.Journal of vascular surgery · 2010Review
- Advances and new frontiers in the pathophysiology of venous neointimal hyperplasia and dialysis access stenosis.Advances in chronic kidney disease · 2009Review
- The source of neointimal cells in vein grafts: does the origin matter?The American journal of pathology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intimal hyperplasia of autologous vein grafts is a critical problem affecting the long-term patency of many types of vascular reconstruction. Within intimal hyperplasia lesions, smooth muscle cells are a major component, playing an essential role in the pathological process. Given that bone marrow-derived cells may differentiate into smooth muscle cells in the neointima of injured arteries, we hypothesized that the bone marrow may serve as a source for some of the smooth muscle cells within intimal hyperplasia lesions of vein grafts. To test this hypothesis, we used an established mouse model for intimal hyperplasia in wild-type mice that had been transplanted with bone marrow from a green fluorescent protein (GFP+/+) transgenic mouse. High-resolution confocal microscopy analysis performed 2 and 8 weeks after grafting demonstrated expression of GFP in 5.4 +/- 0.8% and 11.9 +/- 2.3%, respectively, of smooth muscle cells within intimal hyperplasia lesions. By 16 weeks, GFP expression in smooth muscle cells was not detected by immunohistochemistry; however, real-time PCR revealed that 20.2 +/- 1.7% of the smooth muscle cells captured from the neointima lesion by laser capture microdissection at 16 weeks contained GFP DNA. Our results suggest that bone marrow-derived cells differentiated into smooth muscle cells within the intimal lesion and may provide a novel clinical approach for decreasing intimal hyperplasia in vein grafts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.