ArticleEndocrinology2008
Dehydroepiandrosterone and corticosterone are regulated by season and acute stress in a wild songbird: jugular versus brachial plasma.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 101 citations in OpenAlex.
- Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulfate (DHEA-S) in Broiler Plasma: Analytical Validation of Immunoassays and Comparative Overview Across Avian Species.Animals : an open access journal from MDPI · 2026Article
- Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026Review
- Stress, Well-Being, and Reproduction in Wildlife.Advances in experimental medicine and biology · 2026Review
- Effect of a Broiler-Specific Light Spectrum on Growth Performance and Adrenocortical Activity in Chickens: A Pilot Study on a Commercial Farm.Veterinary sciences · 2024Article
- Stress Concepts and Applications in Various Matrices with a Focus on Hair Cortisol and Analytical Methods.Animals : an open access journal from MDPI · 2022Review
- Quantification of Hair Corticosterone, DHEA and Testosterone as a Potential Tool for Welfare Assessment in Male Laboratory Mice.Animals : an open access journal from MDPI · 2020Article
- Effects of feather processing methods on quantity of extracted corticosterone in broiler chickens.Journal of animal science and technology · 2020Article
- Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters.Hormones and behavior · 2020Article
- Measurement of 11-dehydrocorticosterone in mice, rats and songbirds: Effects of age, sex and stress.General and comparative endocrinology · 2019Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- 3β-HSD expression in the CNS of a manakin and finch.General and comparative endocrinology · 2018Article
- Quantifying corticosterone in feathers: validations for an emerging technique.Conservation physiology · 2018Article
- Neural Androgen Synthesis and Aggression: Insights From a Seasonally Breeding Rodent.Frontiers in endocrinology · 2018Review
- Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals.Conservation physiology · 2018Article
- Baseline and stress-induced levels of corticosterone in male and female Afrotropical and European temperate stonechats during breeding.BMC evolutionary biology · 2017Article
- Steroids in the Avian Brain: Heterogeneity across Space and Time.Journal of ornithology · 2015Article
- Rapid Effects of Estradiol on Aggression in Birds and Mice: The Fast and the Furious.Integrative and comparative biology · 2015Review
- Contextual modulation of social and endocrine correlates of fitness: insights from the life history of a sex changing fish.Frontiers in neuroscience · 2015Review
- Region-specific neural corticosterone patterns differ from plasma in a male songbird.Endocrinology · 2014Article
- Establishing regional specificity of neuroestrogen action.General and comparative endocrinology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stress has well-known effects on adrenal glucocorticoid secretion, and chronic elevation of glucocorticoids can have detrimental effects on the brain. Dehydroepiandrosterone (DHEA), an androgen precursor synthesized in the adrenal glands or the brain itself, has anti-glucocorticoid properties, but little is known about the role of DHEA in the stress response, particularly in the brain. Here, we measured the effects of acute restraint on circulating corticosterone (CORT) and DHEA levels in wild song sparrows. Blood was collected from either the brachial or jugular vein. In songbirds, jugular plasma is enriched with neurally synthesized steroids, and therefore, jugular plasma is an indirect index of the neural steroidal milieu. Subjects were sampled during four times of year: breeding, molt, early nonbreeding, and mid-nonbreeding. Baseline CORT and DHEA levels showed similar seasonal changes; both steroids were elevated during the breeding season. Baseline CORT and DHEA levels were similar in jugular and brachial plasma. Acute stress had robust effects on CORT and DHEA that were season specific and vein specific. For CORT, during the molt, stress increased jugular CORT more than brachial CORT. For DHEA, during the breeding season, stress decreased jugular DHEA but not brachial DHEA. During the molt, stress increased jugular DHEA but not brachial DHEA. Acute stress did not affect brachial DHEA. These data suggest that acute stress specifically affects the balance between DHEA synthesis and metabolism in the brain. Furthermore, these results suggest that CORT and DHEA are locally synthesized in the brain during molt, when systemic levels of CORT and DHEA are low.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.