ArticleThe Journal of physiology2008
Glutamatergic transmission and plasticity between olfactory bulb mitral cells.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Ultrastructural Contributions to Extrasynaptic Glutamatergic Signaling in Olfactory Bulb Glomeruli.The Journal of comparative neurology · 2025Article
- Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb.eLife · 2021Article
- Cellular and Synaptic Mechanisms That Differentiate Mitral Cells and Superficial Tufted Cells Into Parallel Output Channels in the Olfactory Bulb.Frontiers in cellular neuroscience · 2020Article
- Intraglomerular gap junctions enhance interglomerular synchrony in a sparsely connected olfactory bulb network.The Journal of physiology · 2017Article
- Three-dimensional synaptic analyses of mitral cell and external tufted cell dendrites in rat olfactory bulb glomeruli.The Journal of comparative neurology · 2017Article
- Activation of Group II Metabotropic Glutamate Receptors Suppresses Excitability of Mouse Main Olfactory Bulb External Tufted and Mitral Cells.Frontiers in cellular neuroscience · 2017Article
- Zinc as a Neuromodulator in the Central Nervous System with a Focus on the Olfactory Bulb.Frontiers in cellular neuroscience · 2017Review
- Parallel processing of afferent olfactory sensory information.The Journal of physiology · 2016Article
- Sniff-Like Patterned Input Results in Long-Term Plasticity at the Rat Olfactory Bulb Mitral and Tufted Cell to Granule Cell Synapse.Neural plasticity · 2016Article
- Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Postnatal development attunes olfactory bulb mitral cells to high-frequency signaling.Journal of neurophysiology · 2015Article
- Presynaptic T-type Ca2+ channels modulate dendrodendritic mitral-mitral and mitral-periglomerular connections in mouse olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Melatonin in the mammalian olfactory bulb.Neuroscience · 2014Article
- Emergence of connectivity motifs in networks of model neurons with short- and long-term plastic synapses.PloS one · 2014Article
- Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve.Metallomics : integrated biometal science · 2013Article
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- Connexin and AMPA receptor expression changes over time in the rat olfactory bulb.Neuroscience · 2012Article
- Article
- Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Monosynaptic and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the olfactory bulb the sets of mitral cells that project their apical dendrite to the same glomerulus represent unique functional networks. While it is known that mitral cells release vesicular glutamate from their apical tuft it is believed that the resultant self-excitation (SE), transmitted via dendritic gap junctions, is the main form of lateral transmission within the mitral cell assembly. In this study we used simultaneous whole-cell recordings from mitral cell pairs to show that a direct form of chemical lateral excitation (LE) provides a means of mitral cell-mitral cell communication. In contrast to the ubiquitous expression and robust nature of SE, the efficacy of glutamatergic LE between mitral cells is highly variable and mediated by calcium-impermeable AMPA receptors. We also find that the strength of LE is bi-directionally modulated, in a homeostatic manner, by sniffing-like patterns of presynaptic activity. Since these changes last many minutes we suggest that such mitral cell-mitral cell interactions provide the glomerular network with a locus for olfactory plasticity and a potential mechanism for receptive field modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.