ArticleNucleic acids research2008
Transcriptional regulation of NAD metabolism in bacteria: NrtR family of Nudix-related regulators.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 79 citations in OpenAlex.
- Phage-encoded NARP3 system rebuilds NADScience advances · 2026Article
- Regulation of NADPathogens (Basel, Switzerland) · 2025Article
- Characterization of the Nicotinamide Adenine Dinucleotide Biosynthesis Pathway and Regulatory Mechanisms in Streptococcus mutans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- NAD(H) and NADP(H) in plants and mammals.Molecular plant · 2025Review
- Enhancing cellulase biosynthesis ofiScience · 2025Article
- Phages reconstitute NADNature · 2024Article
- Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level.Microbiology (Reading, England) · 2023Review
- New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts.NAR genomics and bioinformatics · 2023Article
- Transcriptome profiling of Nudix hydrolase gene deletions in the thermoacidophilic archaeonFrontiers in microbiology · 2023Article
- Apprehending the NADViruses · 2022Article
- NrtR Mediated Regulation of H1-T6SS in Pseudomonas aeruginosa.Microbiology spectrum · 2022Article
- Proteomic Signatures of Microbial Adaptation to the Highest Ultraviolet-Irradiation on Earth: Lessons From a Soil Actinobacterium.Frontiers in microbiology · 2022Article
- Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners.Molecules (Basel, Switzerland) · 2021Article
- Construction of an Alternative NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Structural analysis and insight into effector binding of the niacin-responsive repressor NiaR from Bacillus halodurans.Scientific reports · 2020Article
- Microbial Musings - December 2020.Microbiology (Reading, England) · 2020Article
- Individual Nudix hydrolases affect diverse features of Pseudomonas aeruginosa.MicrobiologyOpen · 2020Article
- Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.Microbial cell factories · 2020Article
- NADThe Journal of biological chemistry · 2020Article
- A single regulator NrtR controls bacterial NADeLife · 2019Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
A novel family of transcription factors responsible for regulation of various aspects of NAD synthesis in a broad range of bacteria was identified by comparative genomics approach. Regulators of this family (here termed NrtR for Nudix-related transcriptional regulators), currently annotated as ADP-ribose pyrophosphatases from the Nudix family, are composed of an N-terminal Nudix-like effector domain and a C-terminal DNA-binding HTH-like domain. NrtR regulons were reconstructed in diverse bacterial genomes by identification and comparative analysis of NrtR-binding sites upstream of genes involved in NAD biosynthetic pathways. The candidate NrtR-binding DNA motifs showed significant variability between microbial lineages, although the common consensus sequence could be traced for most of them. Bioinformatics predictions were experimentally validated by gel mobility shift assays for two NrtR family representatives. ADP-ribose, the product of glycohydrolytic cleavage of NAD, was found to suppress the in vitro binding of NrtR proteins to their DNA target sites. In addition to a major role in the direct regulation of NAD homeostasis, some members of NrtR family appear to have been recruited for the regulation of other metabolic pathways, including sugar pentoses utilization and biogenesis of phosphoribosyl pyrophosphate. This work and the accompanying study of NiaR regulon demonstrate significant variability of regulatory strategies for control of NAD metabolic pathway in bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.