ArticleDevelopmental biology2008
Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.Development (Cambridge, England) · 2023Article
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- The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.Development (Cambridge, England) · 2022Article
- Reference Transcriptome Data in SilkwormInsects · 2021Article
- A cell atlas of adult muscle precursors uncovers early events in fibre-type divergence in Drosophila.EMBO reports · 2020Article
- Isoform-specific functions of an evolutionarily conserved 3 bp micro-exon alternatively spliced from another exon in Drosophila homothorax gene.Scientific reports · 2020Article
- Genomic and transcriptomic analysis of the Asian honeybee Apis cerana provides novel insights into honeybee biology.Scientific reports · 2018Article
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- 5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila.Scientific reports · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Article
- Cephalopod eye evolution was modulated by the acquisition of Pax-6 splicing variants.Scientific reports · 2014Article
- Article
- Functional association between eyegone and HP1a mediates wingless transcriptional repression during development.Molecular and cellular biology · 2012Article
- 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes.PloS one · 2012Article
- My what big eyes you have: how the Drosophila retina grows.Developmental neurobiology · 2011Review
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- Retinal determination the beginning of eye development.Current topics in developmental biology · 2010Review
- Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila.Developmental biology · 2009Article
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Authors and funding
11 authors.
Funding
Abstract
In eye development the tasks of tissue specification and cell proliferation are regulated, in part, by the Pax6 and Pax6(5a) proteins respectively. In vertebrates, Pax6(5a) is generated as an alternately spliced isoform of Pax6. This stands in contrast to the fruit fly, Drosophila melanogaster, which has two Pax6(5a) homologs that are encoded by the eyegone and twin of eyegone genes. In this report we set out to determine the respective contributions that each gene makes to the development of the fly retina. Here we demonstrate that both eyg and toe encode transcriptional repressors, are expressed in identical patterns but at significantly different levels. We further show, through a molecular dissection of both proteins, that Eyg makes differential use of several domains when compared to Toe and that the number of repressor domains also differs between the two Pax6(5a) homologs. We predict that these results will have implications for elucidating the functional differences between closely related members of other Pax subclasses.
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